Abstract
Background and aims The pathophysiology of spinal cord injury is very complex. One of the debilitating aspects of spinal cord injury in addition to pain is a defect in motor function below the lesion surface. In this study, we tried to assess the modulatory effect of (S)-3,4-Dicarboxyphenylglycine (DCPG), a metabotropic glutamate receptor subtype 8 (mGluR8) agonist, on animal's locomotor functions in a model of compression spinal cord injury. Methods We used a contusion method (T6-T8) for induction of spinal cord injury. Male Wistar rats were randomly assigned to five equal groups (n = 10 per group). Clips compression injury model was used to induce spinal cord injury. Three weeks post injury DCPG, siRNA (small interfering Ribonucleic Acid) and normal saline (vehicle) were administered intra-ventrolaterally to the periaqueductal gray (PAG) region. Motor function, were assessed through BBB (Basso, Beattie, and Bresnahan Locomotor Rating Scale) and ladder walking test. In addition, the effects of DCPG on axonal regeneration in corticospinal tract were evaluated. Results We found that DCPG could improve motor function and axonal regeneration in corticospinal tract when compared to siRNA group. Conclusions The results revealed that...Continue Reading
References
Jan 10, 1990·European Journal of Pharmacology·A I FadenL J Noble
Jun 1, 1988·Annals of Neurology·A I Faden, R P Simon
Jan 1, 1988·Journal of Neurotrauma·A I FadenL J Noble
Jun 1, 1997·Experimental Neurology·J R WrathallR Marriott
Jul 27, 1999·Journal of Neurosurgery·S WadaT Sakou
Oct 12, 2004·Current Drug Targets·Daniel Abankwa, Patrick Küry
Jun 1, 2005·Neuroscience Letters·Guo-Ying XuDavid J McAdoo
Nov 18, 2006·Seminars in Cell & Developmental Biology·David BleakmanEric S Nisenbaum
May 18, 2007·Journal of Neurophysiology·Ida MarabeseSabatino Maione
Feb 29, 2008·Clinics·Tarcisio Eloy Pessoa de Barros Filho, Alessandra Eira Iague Sleiman Molina
Jan 17, 2009·Brain Research Reviews·Cyril GoudetJean-Philippe Pin
Apr 21, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·N AttalT Nurmikko
Mar 2, 2011·Neuroreport·Hua WangYong Li
May 2, 2012·Neuropharmacology·Kari A JohnsonColleen M Niswender
Aug 16, 2014·Cell Reports·Nardos G TassewPhilippe P Monnier
Apr 9, 2015·The Korean Journal of Pain·Farinaz NasirinezhadSajad Salari
Jul 16, 2015·Stem Cells and Development·Zhichao ZhangYong Liu
Sep 5, 2015·The Journal of Spinal Cord Medicine·Farinaz NasirinezhadAutosa Janzadeh
Aug 16, 2017·Trends in Molecular Medicine·Irma VismaraPietro Veglianese
Oct 13, 2017·Basic & Clinical Pharmacology & Toxicology·Anne DindlerMorten Meyer
Feb 25, 2020·Journal of Chemical Neuroanatomy·Atousa JanzadehFarinaz Nasirinezhad