The effect of perioperative beta-blockade on the pulmonary function of patients undergoing major arterial surgery

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
S M KieranM C Barry

Abstract

Concern about the potential detrimental side-effects of beta-blockade on pulmonary function often dissuades against their perioperative use in patients undergoing major arterial surgery (especially in those with chronic obstructive pulmonary disease (COPD)). In this study we aimed to establish prospectively the clinical relevance of these concerns. After ethics committee approval and individual informed consent, the pulmonary function of twenty patients (mean age 68.7 years (range 43-82), 11 males) scheduled to undergo non-emergency major vascular surgery was studied by recording symptoms and spirometry before and after institution of effective beta-blockade. Fifteen patients (75%) had significant smoking histories (mean pack years/patient=50), while 12 (60%) had COPD. All patients tolerated effective beta-blockade satisfactorily without developing either subjective deterioration in symptoms or significant change on spirometry. The mean change in FEV1 following adequate beta-blockade was 0.05+/-0.24 liters (95% CI -0.06 to +1.61), p=0.35, giving a mean percentage change of 3.18%+/-11.66 (95% CI -2.26 to 8.62). Previously held concerns about worsening pulmonary function through the short-term use of beta-blockers should not diss...Continue Reading

References

Mar 21, 2002·JAMA : the Journal of the American Medical Association·Andrew D Auerbach, Lee Goldman
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Citations

Jun 21, 2008·American Journal of Respiratory and Critical Care Medicine·Yvette R B M van GestelDon Poldermans
Jun 12, 2009·International Journal of Chronic Obstructive Pulmonary Disease·Yvette R B M van GestelDon Poldermans

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