Abstract
Previous work has demonstrated that cell-mediated immune function is better preserved in rodents after laparoscopic than open surgery. The cause of this laparotomy-related immunosuppression is unclear. Some investigators have attributed it to the length of the incision; others, to peritoneal air exposure. It has also been shown that tumors in mice are more easily established and grow larger after sham laparotomy than after pneumoperitoneum. Lastly, the differences in tumor growth have been shown to be, at least in part, attributable to the immunosuppression that occurs after laparotomy. The purpose of this study was to determine if air pneumoperitoneum, presumably via immunosuppression related to peritoneal air exposure, is associated with increased tumor growth in the postoperative period. A total of 150 immunocompetent syngeneic mice received high-dose intradermal injections of mouse mammary carcinoma tumor cells. They were then randomized to undergo one of the following procedures: (a) anesthesia alone, (b) air insufflation (44 mm Hg), (c) CO2 insufflation, or (d) full laparotomy. No intraabdominal procedure was carried out. All procedures were 20 min long. After 12 days, the animals were killed and the mean tumor mass deter...Continue Reading
Citations
Nov 7, 2000·Journal of Surgical Oncology·P G Jackson, S R Evans
May 19, 2001·Surgical Endoscopy·J E HartleyJ R Monson
Jun 21, 2002·European Urology·M BöhmE P Allhoff
Nov 18, 2000·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·E F MorenoG B Thompson
May 19, 2000·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M CanisM A Bruhat
Aug 1, 1998·Surgical Endoscopy·R L WhelanH J Bonjer
Oct 27, 1998·Surgical Endoscopy·M Bessler
Aug 21, 2014·Mediators of Inflammation·Shanjun TanNing Li
May 15, 2007·Sarcoma·Scott M M SommervilleRobert J Grimer
Apr 17, 2016·The Journal of Surgical Research·Shan-Jun TanNing Li
Oct 25, 2014·Biological & Pharmaceutical Bulletin·Shanjun TanNing Li
Mar 30, 2016·The Journal of Surgical Research·Shan-Jun TanNing Li
Apr 29, 2008·Journal of Minimally Invasive Gynecology·Nicolas BourdelMichel Canis
Mar 12, 2003·The Journal of Urology·Alexander Tsivian, A Ami Sidi
Aug 8, 2001·The Journal of Urology·M BöhmE P Allhoff
Oct 6, 2016·Experimental and Therapeutic Medicine·Feng ZhouXiaolei Chen