The effect of PGF2 alpha on in vivo cerebral arteriolar diameter in cats and rats

Prostaglandins
E F EllisH A Kontos

Abstract

We compared the effect of topical application of PGF2 alpha on cerebral arterioles in cats and rats equipped with an acutely implanted cranial window. Arterial diameter was measured using a microscope and image splitting device. PGF2 alpha in a concentration ranging from 10(-7) to 10(-5) M had no effect on large (greater than or equal to 100 microns) or small (less than 100 microns) cat pial arterioles, but induced a dose dependent constriction of rat pial arterioles with a maximum constriction to 76% of control diameter. Dilation of cat large cerebral arterioles by topically applied PGE2 was not affected by simultaneous application of PGF2 alpha and PGE2 induced dilation of small arterioles was decreased 3% by PGF2 alpha. While we and others have previously shown that both cat and rat brain can synthesize PGF2 alpha, it appears that PGF2 alpha is not likely to normally be a major modulator of cerebral arteriolar resistance in all species.

References

May 1, 1975·Stroke; a Journal of Cerebral Circulation·J E LevasseurJ L Patterson
Feb 1, 1976·Journal of Neurosurgery·J P KappR P White
Nov 10, 1974·Prostaglandins·M C Koss, J Nakano
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Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J D Pickard

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Citations

Jul 30, 2002·European Journal of Pharmacology·William I RosenblumHermes A Kontos
Mar 14, 2002·Brain Research. Brain Research Reviews·Elke M Golding
Jul 18, 2003·Journal of Neurotrauma·Eiichi SuehiroJohn T Povlishock
Mar 23, 2013·Current Opinion in Neurology·Maria AntonovaMessoud Ashina
Nov 12, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Guoyi GaoJohn T Povlishock
Oct 21, 2011·Cephalalgia : an International Journal of Headache·Maria AntonovaMessoud Ashina
Apr 1, 1997·Stroke; a Journal of Cerebral Circulation·S W HoffmanE F Ellis
Jul 1, 1987·Stroke; a Journal of Cerebral Circulation·R L HaberlE F Ellis

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