The effect of PGF2 alpha on in vivo cerebral arteriolar diameter in cats and rats

E F EllisH A Kontos


We compared the effect of topical application of PGF2 alpha on cerebral arterioles in cats and rats equipped with an acutely implanted cranial window. Arterial diameter was measured using a microscope and image splitting device. PGF2 alpha in a concentration ranging from 10(-7) to 10(-5) M had no effect on large (greater than or equal to 100 microns) or small (less than 100 microns) cat pial arterioles, but induced a dose dependent constriction of rat pial arterioles with a maximum constriction to 76% of control diameter. Dilation of cat large cerebral arterioles by topically applied PGE2 was not affected by simultaneous application of PGF2 alpha and PGE2 induced dilation of small arterioles was decreased 3% by PGF2 alpha. While we and others have previously shown that both cat and rat brain can synthesize PGF2 alpha, it appears that PGF2 alpha is not likely to normally be a major modulator of cerebral arteriolar resistance in all species.


May 1, 1975·Stroke; a Journal of Cerebral Circulation·J E LevasseurJ L Patterson
Feb 1, 1976·Journal of Neurosurgery·J P KappR P White
Nov 10, 1974·Prostaglandins·M C Koss, J Nakano
Feb 1, 1974·European Journal of Pharmacology·K M WelchP Spira
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J D Pickard

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Jul 30, 2002·European Journal of Pharmacology·William I RosenblumHermes A Kontos
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