PMID: 11604258Oct 18, 2001Paper

The effect of pH and concentration upon aggregation transitions in aqueous solutions of poloxamine T701

International Journal of Pharmaceutics
J K ArmstrongS A Leharne

Abstract

Thermally induced aggregation transitions have been investigated for aqueous solutions of the poloxamine block copolymer T701-(OE(4)OP(13))(2)NCH(2)CH(2)N(OP(13)OE(4))(2)-using differential scanning calorimetry. The calorimetric signals obtained were fitted to a mass action model description of aggregation using a previously reported analytical procedure (Patterson et al., Langmuir 13 (1997) 2219). The presence of a central ethylene diamine moiety in the molecular structure renders the T701 molecule basic; this was confirmed and measured by acid/base titration. Basicity is shown to have an important impact upon aggregation. At low pH (2.5), the poloxamine exists in its protonated form and the bulk solution proton concentration is sufficient to suppress de-protonation, aggregation-as a consequence-is shifted to a higher temperature range. Any increase in pH reduces the temperature range over which aggregation occurs. The derived experimental calorimetric parameters, obtained from model fitting procedures, can be used to compute the fraction of poloxamine existing in an aggregated form, at any particular temperature. The data sets obtained were interpolated to show that at human body temperature (310.6 K) the fraction of poloxami...Continue Reading

References

Sep 22, 2000·Trends in Biotechnology·S M Moghimi, A C Hunter

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Citations

Nov 18, 2004·Nucleic Acids Research·Bruno PitardDenis Escande
Jan 16, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Diego A ChiappettaAlejandro Sosnik
May 8, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Diego A Chiappetta, Alejandro Sosnik
Feb 11, 2015·Biomaterials·Peggy Richard-FiardoGeorges Vassaux
Sep 13, 2016·Macromolecular Bioscience·Michael J PoellmannRaphael C Lee
Mar 15, 2019·Molecular Genetics & Genomic Medicine·Francesca AntonarosMaria Caracausi
Sep 13, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Jaime Gonzalez-LopezAngel Concheiro
Jun 28, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Teng LiuFang He
Dec 22, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Eneko Larrañeta, José Ramón Isasi
Oct 24, 2018·The Journal of Physical Chemistry. B·Papu SamantaHaridas Pal
Nov 20, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Suresh Nayana LakshmiSharmistha Dutta Choudhury

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