The effect of pH on the dynamics of natural membranes

The European Physical Journal. E, Soft Matter
M GuiralJ Peters

Abstract

Pure phospholipids and membrane fragments from bacterial cells living under various conditions were studied against the influence of the surrounding acidity on the internal dynamics. For that we compared mean square displacements extracted from elastic incoherent neutron scattering data, measured both at low and at neutral pH, of the phospholipids 1,2-dimyristoyl-sn-glycero-3-phosphocholine and of samples from neutralophilic and acidophilic micro-organisms (some being hyperthermophilic and others mesophilic). The lipids showed a slight shift in the phase transition temperature of about 4 degrees under pH variation and became slightly more mobile at lower pH. The membrane fragments not used to extreme acidic conditions were significantly more sensitive to variations in the pH values, whereas the acidophilic and -tolerant samples were much less influenced by this parameter. They presented the higher softness at low pH, which was closer to their native condition. Such findings might be a hint for adaptation mechanisms to different acidity conditions.

References

Dec 1, 1987·Protein Engineering·M Vihinen
Jan 1, 1994·Archives of Microbiology·J LorenzenG Unden
Jun 27, 2000·Journal of Biotechnology·R Jaenicke
Jun 1, 1961·Journal of Bacteriology·M J WOLINN J JACOBS
Dec 9, 2003·Journal of Inorganic Biochemistry·Artur Krezel, Wojciech Bal
Dec 17, 2004·Journal of Bacteriology·Lisa M MaurerJoan L Slonczewski
Jan 26, 2005·Biochemical Society Transactions·M GuiralM-T Giudici-Orticoni
Oct 21, 2005·The Journal of Biological Chemistry·Marianne GuiralMarie-Thérèse Giudici-Orticoni
Feb 19, 2010·Journal of the American Chemical Society·Sebastian BuschTobias Unruh
Nov 10, 2013·Physical Chemistry Chemical Physics : PCCP·Marcus TrappJudith Peters
Jun 6, 2014·FEMS Microbiology Reviews·Peter LundDaniela De Biase
Apr 12, 2015·FEMS Microbiology Reviews·Christian Sohlenkamp, Otto Geiger
May 13, 2014·Journal of Chemical Theory and Computation·Vitor H TeixeiraMiguel Machuqueiro
Nov 21, 2015·Journal of Chemical Theory and Computation·Hugo A F SantosMiguel Machuqueiro
Oct 27, 2016·Journal of the American Chemical Society·Stefania PerticaroliJonathan D Nickels
Oct 3, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Toshihiko OkaMasahito Yamazaki

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Citations

Jul 18, 2021·Biochimica Et Biophysica Acta. Biomembranes·Anindya ChowdhuryV A Raghunathan

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