PMID: 1202817May 1, 1975Paper

The effect of phenamine on the avoidance reaction in intact and striatectomized rats

Zhurnal vyssheĭ nervnoĭ deiatelnosti imeni I P Pavlova
E B Arushanian, V A Baturin

Abstract

Various characteristics of a conditioned avoidance reaction were recorded in rats in a Y-maze. Small doses of d,l-amphetamine (0.5 mg/kg) facilitated avoidance response while large ones (5 mg/kg) worsened it. After ablation of the rostral part of the striatum, small doses of the drug had the same effect as before, but no deteriorating action of large doses was observed. The behaviour disturbance is related to the capacity of d,l-amphetamine for activating the nigro-striatal dopaminergic transmission.

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.