Jan 1, 1982

The effect of phentolamine on synaptosomal phosphatidylinositol in experimental galactose toxicity

Neurochemical Research
G T BerryS Segal

Abstract

Abnormal myo-[2-3H]inositol incorporation into phosphatidylinositol has been found in phentolamine-treated synaptosomes that were isolated from the cerebral hemispheres of galactose toxic rats and incubated with [33P]Pi and myo-[2-3H] inositol. In galactose toxic rats phentolamine-stimulated myo-[2-3H]inositol labeling of phosphatidylinositol was 70% greater than in normal animals. This enhanced labeling of synaptosomal phosphatidylinositol in galactose toxic rats during stimulation with phentolamine is in marked contrast to the depressed myo-inositol labeling of phosphatidylinositol reported with acetylcholine stimulation.

  • References8
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Mentioned in this Paper

Z-Max
Phosphatidylinositols
Brain
Galactose
Drug-Induced Liver Injury
Synaptosomes
Inositol

About this Paper

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