Dec 1, 1972

The effect of phospholipids on anaphylactic histamine release

British Journal of Pharmacology
J L Mongar, P Svec

Abstract

1. Histamine release by antigen from three sensitized rat tissues is potentiated by phosphatidyl serine (PS). The effect is greatest with isolated peritoneal cells. Phosphatidyl inositol, ethanolamine, choline and phosphatidic acid are inactive.2. PS greatly increases the rate of antigen-induced histamine release and only slightly prolongs the duration of the release process.3. PS shows a concentration-dependent effect over the range 1-10 mug/ml. At 10 mug/ml it is active over a wide range of antigen concentrations.4. Calcium ions are necessary for the potentiation by PS of antigen-induced histamine release from rat peritoneal cells.

Mentioned in this Paper

Choline
Phosphatidylinositols
Lung
Mast Cell
Calcium
Phosphatidylserines
Immediate Hypersensitivity
Action Potentials
Calcium ion
Mesentery

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