The effect of physical training on insulin secretion of rat pancreatic islets

Acta Physiologica Scandinavica
H GalboJ Vinten

Abstract

Rats were either physically trained by a 12-wk swimming program or were freely eating or weight matched, sedentary controls. Islets of Langerhans were isolated and incubated in various glucose concentrations. Within the range of physiological glucose concentrations the rate of insulin release from islets of trained rats was lower than that from islets of sedentary controls. The DNA content of the islets was similar in the different groups. The demonstrated decreased glucose sensitivity of the insulin secretory mechanism within the beta-cells of trained rats may partly explain the finding of lower plasma insulin concentrations during intravenous glucose tolerance test in these rats compared with sedentary rats. Epididymal fat pads of trained rats were smaller than those of weight matched controls which in turn were smaller than those of freely eating controls, these differences being due to differences in fat cell size. The lower glucose sensitivity of the beta-cells in trained rats was probably not a consequence of the low body weight and small fat depots in these rats

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Citations

Apr 18, 2001·Diabetes/metabolism Research and Reviews·E J Mayer-DavisUNKNOWN Insulin Resistance Atherosclerosis Study (IRAS)
Dec 2, 1991·Mechanisms of Ageing and Development·J L IvyJ O Holloszy
Jan 1, 1989·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·S E Terblanche
Oct 29, 1993·Annals of the New York Academy of Sciences·D Richard
May 5, 2012·Diabetes/metabolism Research and Reviews·Jacqueline L Beaudry, Michael C Riddell
Dec 6, 2012·Biochemical and Biophysical Research Communications·Miho TsuchiyaNobuharu L Fujii
Jan 1, 1986·Diabetes/metabolism Reviews·S H SchneiderN Ruderman
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Mar 21, 2015·Journal of Applied Physiology·Jacqueline L BeaudryMichael C Riddell
Jan 1, 1986·Diabetes/metabolism Reviews·H Galbo
Jun 6, 2018·Frontiers in Physiology·Veridiana Mota MoreiraPaulo Cezar de Freitas Mathias
Jan 1, 1986·Acta Medica Scandinavica. Supplementum·J O HolloszyA A Ehsani
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Aug 1, 1990·The American Journal of Physiology·D S KingJ O Holloszy
Feb 1, 1983·The American Journal of Physiology·J Vinten, H Galbo

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