The effect of physiologic derangement in patients with stroke treated with thrombolysis

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
T IdiculaL Thomassen

Abstract

Body temperature, blood glucose, and blood pressure (BP) may interfere with outcome in patients with acute ischemic stroke treated with thrombolysis. We prospectively studied 127 patients who received thrombolysis with tissue plasminogen activator for acute stroke in Bergen, Norway. Body temperature, blood glucose, and BP were measured before thrombolysis. Maximum body temperature and maximum blood glucose within the first 5 days after thrombolysis and maximum BP within the first 24 hours after thrombolysis were measured. The outcome was measured with modified Rankin scale score obtained at 3 months after stroke onset. Variables were tested using multiple logistic regression analysis after adjusting for National Institute of Health Stroke Scale score before thrombolysis and potential confounders. The average age of the patients was 63 years and the median National Institute of Health Stroke Scale score was 13. On admission, diabetes mellitus was present in 6% of patients and hypertension in 51% of patients. High body temperature and high blood glucose after thrombolysis were associated with poor prognosis (odds ratio [OR] 2.84, 95% confidence interval [CI] 1.29-6.25, P = .01; OR 1.33, 95% CI 1.02-1.74, P = .03). High body tempe...Continue Reading

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Citations

Apr 18, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Marjaana TiainenUNKNOWN Helsinki Stroke Thrombolysis Registry Group
Aug 10, 2018·Acta Neurologica Scandinavica·Tatsuya UenoMasahiko Tomiyama
Jun 24, 2017·Journal of the American Heart Association·Sung-Chun TangUNKNOWN Taiwan Stroke Registry Investigators
Dec 3, 2016·BMC Neurology·Marjolein GeurtsUNKNOWN DUST investigators

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