The effect of phytohaemagglutinin at different dietary concentrations on the growth, body composition and plasma insulin of the rat

The British Journal of Nutrition
S BardoczA Pusztai

Abstract

Young growing rats weighing approximately 83 g were fed on diets containing kidney bean (Phaseolus vulgaris) lectin (phytohaemagglutinin, PHA) in the range of 0-0.45 g/kg body weight for 10 d to ascertain whether there was a minimum dose below which the lectin had no significant effect on body and skeletal muscle weights in comparison with pair-fed lectin-free controls. Averaged over all experiments, PHA doses of less than 10 mg/d (0.12 g/kg body weight) reduced body dry by 1.14 (SE 0.25) g when compared with controls. Between 10 and 27 mg/d (0.12-0.32 g/kg body weight) a further reduction of 0.64 (SE 0.21) g occurred, suggesting a slight but steady decline of body dry weight with increasing dose. However, above 27 mg/d the depression of growth and changes in body composition accelerated. The difference between the proportional losses of skeletal muscle and body weight was not significant at doses of PHA below 10 mg/d (0.12 g/kg body weight) but the ratio of these losses rose to 1.5-2.0 at doses above this. The proportional decrease in lipid weight exceeded that of both body and skeletal muscle weights at all lectin doses, suggesting that lipid catabolism was the first target of the PHA effect. Plasma insulin level was depresse...Continue Reading

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