The effect of plasma human immunodeficiency virus RNA and CD4(+) T lymphocytes on growth measurements of hemophilic boys and adolescents

Pediatrics
M W HilgartnerHemophilia Growth and Development Study

Abstract

The investigation examined the associations of plasma human immunodeficiency virus (HIV) RNA and CD4(+) T lymphocytes with height, weight, skeletal maturation, testosterone levels, and height velocity for hemophilic children and adolescents with HIV infection in the Hemophilia Growth and Development Study. Two hundred seven participants were evaluated over 7 years. A threefold increment in baseline plasma HIV RNA was associated with a 0.98-cm decrease in height and a 1.67-kg decrease in weight; 100-cells/microL decrements in baseline CD4(+) were associated with a 2.51-cm decrease in height and a 3.83-kg decrease in weight. Participants with high plasma HIV RNA (>3125 copies/mL) experienced significant delay in achieving maximum height velocity and lower maximum velocity compared with those with low viral load. The high CD4(+) (>243)/low plasma HIV RNA group had earlier age at maximum height velocity compared with the other 3 groups and higher maximum height velocity compared with the low CD4(+)/high plasma HIV RNA and low CD4(+)/low plasma HIV RNA groups. Decrements in CD4(+) were associated with decreases in bone age and testosterone level. CD4(+) and HIV RNA were important in predicting growth outcomes.

Citations

Dec 23, 2003·The Pediatric Infectious Disease Journal·Caroline J ChantryUNKNOWN Pediatric AIDS Clinical Trials Group Protocol 152 Study Team
Oct 16, 2009·Journal of Developmental and Behavioral Pediatrics : JDBP·Patricia A SiroisUNKNOWN IMPAACT/PACTG 219C Team
Aug 24, 2007·Blood·Sharyne M DonfieldUNKNOWN Hemophilia Growth and Development Study Group
Jun 7, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kate BuchaczUNKNOWN Pediatric AIDS Clinical Trials Group 219 Study Team
Apr 13, 2012·Advances in Virology·P GernerS Wirth
Jun 11, 2005·São Paulo Medical Journal = Revista Paulista De Medicina·Maraisa CentevilleMaria Marluce dos Santos Vilela

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