PMID: 3034367Apr 1, 1987Paper

The effect of platelet activating factor on pulmonary beta-adrenoceptors

British Journal of Pharmacology
P J BarnesD N Robertson


An intravenous infusion of platelet activating factor (Paf) in the guinea-pig elicits an increase in bronchial responsiveness to the spasmogens, histamine and bombesin. Airways obstruction induced by bombesin in Paf-treated animals is poorly reversed by isoprenaline compared to comparable airways obstruction induced by bombesin in vehicle-treated animals. Isoprenaline induced a comparable dose-related relaxation in vitro of tracheal smooth muscle isolated from Paf- and vehicle-treated animals. No change in beta-adrenoceptor numbers or binding affinity was observed in lungs removed from Paf-treated animals in comparison with those from vehicle-treated animals, or after direct incubation with Paf in vitro. The reduced bronchodilator responsiveness to isoprenaline in Paf-treated animals is not related to changes in pulmonary beta-adrenoceptor function. These results suggest that non-spasmogenic elements may contribute to airways obstruction induced in hyper-responsive animals.


May 1, 1985·Clinical Reviews in Allergy·W J MetzgerH B Richerson
Jul 30, 1983·Lancet·D W Cockcroft
Nov 17, 1984·Lancet·J MorleyC P Page
Jul 1, 1980·Circulation Research·S WallensteinJ L Fleiss


Jan 1, 1990·Lung·Peter J Barnes
Mar 13, 1990·European Journal of Pharmacology·L DaffonchioC Omini
Jan 1, 1990·Pharmacology & Therapeutics·R G GoldieK M Lulich
Feb 1, 1988·Trends in Pharmacological Sciences·C P Page
Jan 1, 1990·British Journal of Clinical Pharmacology·C P Page
Dec 1, 1992·British Journal of Pharmacology·K TashiroY Ito
Jan 1, 1990·Molecular Aspects of Medicine·Peter J Barnes
Jan 1, 1990·Experimental Lung Research·C J DoelmanA Bast
Sep 1, 1987·British Journal of Pharmacology·D N Robertson, C P Page
Jan 1, 1988·Fundamental & Clinical Pharmacology·J FichelleC Advenier
Jul 1, 1988·British Journal of Pharmacology·L DaffonchioB J Whittle
Aug 30, 2016·Molecular Pharmaceutics·Aateka PatelC P Page
May 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S C StentonE H Walters
Jan 1, 1991·Annals of the New York Academy of Sciences·Peter J Barnes
Mar 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Peter J Barnes
Jan 1, 1991·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·S B FelixW E Berdel
Jun 24, 1998·Biochemical and Biophysical Research Communications·F VisioliC Galli

Related Concepts

Cavia porcellus
Platelet Activating Factor
Beta-adrenergic receptor

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