The effect of platelet autoantibodies on the course of the disease and clinical response of patients with idiopathic thrombocytopenic purpura

International Journal of Laboratory Hematology
A SikorskaK Maślanka

Abstract

In this study, we evaluated the response to treatment of 409 idiopathic thrombocytopenic purpura (ITP) patients who were tested for the presence of platelet-associated autoantibodies by direct-platelet immunofluorescence test (PIFT) and for the presence of plasma antibodies directed against the GPIIb/IIIa, GPIb and GPIa/IIa by monoclonal antibody immobilization of platelet antigens (MAIPA). In patients with platelet autoantibodies in comparison with patients without antibodies more frequently were observed the chronic form of disease (83.5%vs. 68.5%) and severe symptoms of haemorrhage diathesis (17.3%vs. 6.9%). Evaluation of the treatment response (to corticosteroids, immunosuppressive drugs and splenectomy) referred to patients with complete response, e.g. complete remission defined as platelet count of >100 x 10(9)/l for at least 2 years. The percentage of complete response in the whole population of ITP patients, both with and without autoantibodies regardless of the method of treatment, was similar (about 54%). However, the presence of platelet autoantibodies had effect on patients treated with corticosteroids: complete response approximately 71% (36/51) of patients with autoantibodies and in 60% (72/120) of patients withou...Continue Reading

References

Jun 1, 1978·British Journal of Haematology·A E von dem BorneC P Engelfriet
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Jan 30, 1995·American Journal of Medical Genetics·J L KennedyM Perkins
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Feb 3, 2004·American Journal of Hematology·K MaślankaB Zupańska
Jul 4, 2006·Seminars in Hematology·James Bussel

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Citations

May 21, 2013·Hematology·Jecko Thachil
May 8, 2010·Annals of Hematology·John David GraingerAndre Tichelli
Feb 20, 2020·Journal of Veterinary Internal Medicine·Sarah ShropshireMichael Lappin
May 29, 2010·Platelets·Jianhui XuRenchi Yang

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