The effect of platelet-rich fibrin membrane on the repair of perforated tympanic membrane: an experimental study

Acta Oto-laryngologica
Nuray EnsariÜstün Osma

Abstract

Platelet-rich fibrin (PRF) membrane could be used successfully in the repair of tympanic membrane perforation and wound healing. To evaluate the effect of platelet-rich fibrin membrane in the repair of perforated tympanic membrane. After otoscopic examination, a 3-mm perforation was made in the posterior quadrant of both tympanic membranes of 50 adult male Sprague-Dawley rats. Venous blood was withdrawn from the rats, then centrifuged. PRF was obtained in membrane form. The membrane was placed on the right tympanic membrane perforation. The perforations on the left side were left to spontaneously heal and, thus, formed the control group. Daily examinations were made of 20 rats and the time to healing of the tympanic membrane was recorded. The remaining 30 rats were separated into five groups of six, and histopathological examination was made. Evaluation was made in respect of the presence of oedema in the lamina propria, neovascularization, fibroblastic reaction, and inflammatory cells. The healing time of the tympanic membrane perforation was determined as mean 10.3 ± 2.18 days in the study group applied with PRF and 17 ± 2.40 days in the control group. Higher values in respect of fibrosis and neovascularization were obtained ...Continue Reading

References

Jan 1, 1991·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·S H Schmidt, S Hellström
Oct 23, 2002·The Annals of Otology, Rhinology, and Laryngology·Shin-ichi Ishimoto, Toshio Ishibashi
Mar 17, 2005·Acta Oto-laryngologica·Wu-Qing WangFang-Lu Chi
Mar 1, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·David M DohanBruno Gogly
Mar 1, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·David M DohanBruno Gogly
Oct 29, 2008·The Journal of Laryngology and Otology·E ErkiletM Yarim
Nov 6, 2008·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·F T Orji, C C Agu
Dec 18, 2009·American Journal of Otolaryngology·Kyu-Sup ChoKyong-Myong Chon
Sep 3, 2013·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Sunita Chhapola, Inita Matta
Dec 3, 2013·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·T Santhi, K V Rajan
Sep 10, 2014·Auris, Nasus, Larynx·Taylan GunCemal Cingi
Mar 22, 2015·Auris, Nasus, Larynx·Mohammad Waheed El-AnwarMohammad Abdel-Rhman Abdel-Salam Yacoup
Mar 11, 2016·Aesthetic Surgery Journal·Ali GöralMustafa Durgun
Oct 1, 2016·International Journal of Surgery Case Reports·Antonio CorteseMassimo Amato

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Citations

Feb 13, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Belgin TutarYavuz Uyar
Jan 14, 2020·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Andrea Acebes-HuertaLaura Gutiérrez
Jun 5, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Juntao HuangYi Shen

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