The effect of platelet-rich plasma on osseous healing in dogs undergoing high tibial osteotomy

PloS One
Samuel P FranklinShannon P Holmes

Abstract

The purpose of this study was to investigate whether platelet-rich plasma (PRP) enhances osseous healing in conjunction with a high tibial osteotomy in dogs. Randomized controlled trial. Sixty-four client-owned pet dogs with naturally occurring rupture of the anterior cruciate ligament and that were to be treated with a high tibial osteotomy (tibial plateau leveling osteotomy) were randomized into the treatment or control group. Dogs in the treatment group received autologous platelet-rich plasma activated with calcium chloride and bovine thrombin to produce a well-formed PRP gel that was placed into the osteotomy at the time of surgery. Dogs in the control group received saline lavage of the osteotomy. All dogs had the osteotomy stabilized with identical titanium alloy implants and all aspects of the surgical procedure and post-operative care were identical among dogs of the two groups. Bone healing was assessed at exactly 28, 49, and 70 days after surgery with radiography and ultrasonography and with MRI at day 28. The effect of PRP on bone healing was assessed using a repeated measures analysis of covariance with radiographic and ultrasonographic data and using a t-test with the MRI data. Sixty dogs completed the study. Ther...Continue Reading

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Citations

Jul 17, 2020·Frontiers in Bioengineering and Biotechnology·Stuart B Goodman, Tzuhua Lin
Sep 15, 2018·Current Reviews in Musculoskeletal Medicine·Alexander WassermanPeter MacDonald
Nov 11, 2020·Journal of Orthopaedic Surgery and Research·Haitao ZhangYirong Zeng
Sep 2, 2020·Trends in Biotechnology·Carla S SoaresManuela E Gomes
Nov 17, 2020·Frontiers in Veterinary Science·Barry ChernoSherman Canapp

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Methods Mentioned

BETA
lavage

Software Mentioned

Osirix

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