The effect of pneumococcal conjugate vaccines on the incidence of invasive pneumococcal disease caused by ten non-vaccine serotypes in Denmark

Vaccine
Hans-Christian SlotvedSteen Hoffmann

Abstract

Surveillance data on invasive pneumococcal disease (IPD) in Denmark (1999-2014) was analysed regarding the incidence and age-distribution due to ten selected non-PCV serotypes (10-Non-PCV). The effect of PCV-7 and PCV-13 vaccines on the 10-Non-PCV IPD incidence was examined. IPD cases caused by serotypes included in PCV-7, the additional six serotypes included in PCV-13 and 10-Non-PCV serotypes were identified (8, 9N, 11A, 12F, 15A, 22F, 24F, 20, 23B, 33F). The IPD incidence was stratified by three age groups: 0-4 years, 5-64 years and 65+ years. The predominant IPD cases were caused by serotypes that are not included in PCV-13 (71%), followed by the six additional PCV-13 serotypes. The IPD incidence of serotypes included in the PCV-7 decreased markedly after PCV-7 introduction but are still diagnosed at a low level. The IPD incidence for the 10-Non-PCV serotypes was low for age groups 0-4 years and 5-64 years but high for 65+ years. Future vaccinations of the young age group alone with a vaccine targeting some of the 10-Non-PCV serotypes may not elicit the desired effect on herd protection since these serotypes are primarily causing IPD among the elderly. Future pneumococcal vaccination strategies in Denmark may therefore need...Continue Reading

References

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Citations

Jun 21, 2016·Human Vaccines & Immunotherapeutics·Hans-Christian Slotved
Jun 3, 2017·Human Vaccines & Immunotherapeutics·Ayşe BüyükcamMehmet Ceyhan
Nov 1, 2017·PloS One·Elizabeth T Cafiero-FonsecaDavid E Bloom
Oct 13, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nirma Khatri VadlamudiFawziah Marra
Jul 4, 2019·Journal of Medical Microbiology·Lucia Gonzales-SilesEdward R B Moore
Nov 5, 2019·Expert Review of Vaccines·Myint Tin Tin HtarDavid Swerdlow
Oct 19, 2017·Scientific Reports·Hans-Christian SlotvedDidrik F Vestrheim
Apr 4, 2019·Scientific Reports·Ioanna Drakaki KavalariH-C Slotved
Feb 10, 2017·BMC Infectious Diseases·Eric S DonkorHans-Christian Slotved
Mar 27, 2020·Frontiers in Public Health·Hans-Christian Slotved, Steen Hoffmann
Sep 19, 2020·Emerging Infectious Diseases·Reiko ShimbashiUNKNOWN Adult IPD Study Group
Apr 4, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Travis ShuteElizabeth A Leadbetter
May 7, 2021·BMC Infectious Diseases·Camilla Bülow HansenH-C Slotved

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