PMID: 14392238Jul 1, 1955Paper

The effect of poliomyelitis virus on human brain cells in tissue culture

The Journal of Experimental Medicine
M J HOGUEL L CORIELL

Abstract

Poliomyelitis virus I, Mahoney strain, affected human brain cells grown in tissue cultures usually causing death of the cells in 3 days. The neurons reacted in different ways to the virus, some died with their neurites extended, others contracted one or more of their neurites. Terminal bulbs were frequently formed at the tips of the neurites when they were being drawn into the cell body. The final contraction of the cell body and the change into a mass of granules were often very sudden. Vacuoles often developed in the neuron. There was no recovery. Astrocytes, oligodendroglia, and macrophages were affected by the virus but not as quickly as the neurons. The age of the tissue culture was not a factor when the cells were in good condition. The age of the individual donor of the brain tissue was a factor; the fetal brain cells appeared to be more sensitive to the virus than the adult brain cells. The fetal neurons often reacted (1/2) hour after inoculation while the adult neurons reacted more slowly, 2 to 24 hours after inoculation. All these changes seemed to be caused by virus infection because they were prevented by specific antiserum or by preheating the virus.

References

Nov 1, 1953·The American Journal of Anatomy·M J HOGUE
Nov 17, 1954·Annals of the New York Academy of Sciences·J F ENDERS
Jan 1, 1955·Proceedings of the Society for Experimental Biology and Medicine·G BARSKIM ENDO
Mar 1, 1949·The Anatomical Record·M J HOGUE

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Citations

Jan 1, 1956·Archiv für die gesamte Virusforschung·S M BUCKLEY
Sep 1, 1956·The Journal of Experimental Medicine·D W HOWESM REISSIG
May 17, 2018·Journal of the History of the Neurosciences·Steven J Zottoli, Ernst-August Seyfarth
Nov 30, 1962·Annals of the New York Academy of Sciences·S A PLOTKINA F GRAHAM

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