The effect of poly(ethylene glycol) coating on colloidal stability of superparamagnetic iron oxide nanoparticles as potential MRI contrast agent

International Journal of Pharmaceutics
Afshin MasoudiMohammad Ali Oghabian

Abstract

Superparamganetic iron oxide-based contrast agents in magnetic resonance imaging (MRI) have offered new possibility for early detection of lymph nodes and their metastases. According to important role of nanoparticle size in biodistribution, magnetite nanoparticles coated with different polyethylene glycol (PEG) concentrations up to 10/1 PEG/iron oxide weight ratio in an ex situ manner. To predict the PEG-coated nanoparticle behavior in biological media, such as blood stream or tissue, colloidal stability evaluation was performed to estimate the coating endurance in different conditions. Accordingly, optical absorbance measurements were conducted in solutions with different values of pH and NaCl concentrations. The results indicated that at neutral pH condition, nanoparticles treated by 3/1 ratio possessed better stability parameters. Investigating at high pH of 10 resulted in superior stability for bare magnetite nanoparticles due to its higher electrophoretic mobility. Coating material was attacked at acidic solutions which cause samples with higher PEG weight ratio to be settled slower. In various ionic strengths of 10(-5) to 0.1 M, 3/1 ratio samples offered greater resistivity to sedimentation. The nanoparticles were furthe...Continue Reading

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