The effect of pore size and porosity on mechanical properties and biological response of porous titanium scaffolds

Materials Science & Engineering. C, Materials for Biological Applications
C Torres-SanchezP P Conway

Abstract

The effect of pore size and porosity on elastic modulus, strength, cell attachment and cell proliferation was studied for Ti porous scaffolds manufactured via powder metallurgy and sintering. Porous scaffolds were prepared in two ranges of porosities so that their mechanical properties could mimic those of cortical and trabecular bone respectively. Space-holder engineered pore size distributions were carefully determined to study the impact that small changes in pore size may have on mechanical and biological behaviour. The Young's moduli and compressive strengths were correlated with the relative porosity. Linear, power and exponential regressions were studied to confirm the predictability in the characterisation of the manufactured scaffolds and therefore establish them as a design tool for customisation of devices to suit patients' needs. The correlations were stronger for the linear and the power law regressions and poor for the exponential regressions. The optimal pore microarchitecture (i.e. pore size and porosity) for scaffolds to be used in bone grafting for cortical bone was set to <212μm with volumetric porosity values of 27-37%, and for trabecular tissues to 300-500μm with volumetric porosity values of 54-58%. The po...Continue Reading

Citations

Sep 16, 2020·Journal of Orthopaedic Surgery and Research·Linwei LyuJikun Wang
May 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Biranche TandonSarah H Cartmell
Jan 2, 2019·BioMed Research International·Yanbo ZhangYanguo Qin
Jul 7, 2020·Frontiers in Bioengineering and Biotechnology·Hao ChenJincheng Wang
Mar 13, 2021·Acta Biomaterialia·H M A KolkenA A Zadpoor
Dec 17, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Kenny A van KampenCarlos Mota
May 6, 2021·Materials Science & Engineering. C, Materials for Biological Applications·C Torres-SanchezP P Conway
Oct 31, 2020·Environmental Science & Technology·Conghui HuangThanh H Nguyen
Nov 11, 2019·ACS Biomaterials Science & Engineering·Qing HanJincheng Wang
Dec 4, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ping Xia, Yongxiang Luo

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