The effect of porosity and mechanical property of a synthetic polymer scaffold on repair of osteochondral defects.

International Orthopaedics
Risa IkedaMasahiro Kurosaka

Abstract

We have made three types of poly (DL-lactide-co-glycolide) (PLG) scaffolds (porosity: scaffold I 80 +/- 0.9%, II 85 +/- 0.8%, III 92 +/- 0.7%; compression module determined with 10% strain: scaffold I 0.26 MPa, II 0.091 MPa, III 0.0047 MPa). Osteochondral defects made in the femoral condyle of rabbits were treated with these scaffolds and the possibilities of cartilage repair were investigated histologically. At post-operative weeks 6 and 12, histological scores in the groups of scaffolds II and III were significantly higher than the score in the group of scaffold I. Scaffolds II and III, which have higher porosity than scaffold I, allow better migration of bone marrow cells and better replacement of the scaffold with bone and cartilage than scaffold I. This study suggests that higher porosity allowing bone marrow cells to migrate to the scaffold is important in repairing osteochondral defects.

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Citations

Dec 5, 2009·International Orthopaedics·Atsuyuki InuiMasahiro Kurosaka
Sep 15, 2012·International Orthopaedics·Hanako NishimotoMasahiro Kurosaka
Nov 13, 2009·Tissue Engineering. Part a·Sook Young ParkHyun Jeong Kim
Mar 29, 2014·Journal of Materials Science. Materials in Medicine·Iska DresingDavid Eglin
Jun 26, 2014·International Orthopaedics·Nadomir GusićSaša Janković
Jan 5, 2014·International Orthopaedics·Ryosuke SakataMasahiro Kurosaka
Jun 15, 2011·Journal of Materials Science. Materials in Medicine·Rula M Allaf, Iris V Rivero
Feb 4, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Roman A Perez, Gemma Mestres
Oct 13, 2012·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Atsuyuki InuiHiroyuki Fujioka
Aug 21, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mi Ra JungSeung Jin Lee
Aug 11, 2015·Carbohydrate Polymers·Guowei WangHiroshi Uyama
Dec 10, 2015·Acta Cirúrgica Brasileira·Paulo Cezar Vidal Carneiro de AlbuquerqueCarina Scanoni Maia
Mar 7, 2018·Journal of Biological Physics·Ágata PaimPatricia Pranke
Oct 2, 2013·Chemical Communications : Chem Comm·Yanming WangYong Huang
Sep 26, 2020·Frontiers in Bioengineering and Biotechnology·Joseph G LyonsSilvia Minardi
Mar 5, 2021·Frontiers in Bioengineering and Biotechnology·Martina TortoriciSara Checa
May 29, 2021·Bulletin of Experimental Biology and Medicine·E A AkoulinaA P Bonartsev
Apr 13, 2015·ACS Biomaterials Science & Engineering·Le-Ping YanRui L Reis

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