The effect of post mastectomy radiation therapy on breast reconstruction with and without acellular dermal matrix: a systematic review and meta-analysis protocol

Systematic Reviews
Amy M ChungJing Zhang

Abstract

The widespread implementation of acellular dermal matrix (ADM) has broadened the reconstructive repertoire for alloplastic breast reconstruction. ADM's role in the context of postoperative radiation therapy remains unclear. The present review will evaluate whether ADM reduces complication rates in patients undergoing post-mastectomy radiation therapy (PMRT). A healthcare librarian assisted in performing a search strategy of electronic databases MEDLINE (via Ovid), EMBASE, and CENTRAL. A combination of the keywords and Medical Subject Headings (MESH) to describe the various commercially available ADMs and terms for radiation therapy will be used. The search strategy will identify patients undergoing postoperative radiation following implant-based breast reconstruction and compare outcomes between those with and without ADM. Extracted data will include patient demographics, intraoperative data, and postoperative complications. Data on patient satisfaction and resource utilization will also be extracted if available. The references of selected works will be reviewed for additional studies meeting study criteria. Only peer-reviewed papers written in English will be included. The study data will be assessed for risk of bias and hete...Continue Reading

References

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Feb 4, 2010·Plastic and Reconstructive Surgery·Yoon S ChunElof Eriksson
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Citations

Aug 29, 2019·Plastic and Reconstructive Surgery·Allen Gabriel, G Patrick Maxwell
Feb 11, 2020·Annals of Plastic Surgery·Patrick S CottlerChris A Campbell
Jun 22, 2021·Systematic Reviews·Petmore ZibakoThemba G Ginindza

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Software Mentioned

Ovid
BREAST
Cochrane Risk of Bias
Review Manager ( RevMan )
Risk Of Bias In Non - randomized Studies - of Interventions ( ...

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