The effect of post-mortem computed tomography angiography (PMCTA) using water-soluble, iodine-based radiographic contrast on histological analysis of the liver, kidneys and left ventricle of the heart

Forensic Science, Medicine, and Pathology
Samantha HigginsChris O'Donnell

Abstract

The purpose of this study was to investigate the impact of post-mortem computed-tomography angiography (PMCTA) on the histology of the liver, kidneys and heart. Multiple tissue cores were collected from the liver, left and right kidneys and left ventricle utilizing CT-guided biopsy. Subsequent whole body PMCTA was performed using a solution of polyethylene glycol and iodinated radiographic contrast, and an embalming pump. Corresponding biopsy cores were collected at autopsy, and blinded histology analysis assessing for PMCTA-induced histology artefact was performed. The blinded analysis of pre-PMCTA and post-PMCTA biopsy samples demonstrated that whole body PMCTA had no effect on the histological analyses of the liver (0%, CI = 0-13.7%), left ventricle of the heart (0%, CI = 0-36.9%) and right kidney (0%, CI = 13.2%), however likely caused increased Bowman's capsule spaces in the left kidney of one case (4%, CI = 0.01-20.4%). Other artefactual histological changes identified included eosinophilic material in the liver, whiter interstitium and dilated tubules in kidney samples, and autolysis-related changes, however these could not be categorically attributed to the PMCTA procedure. PMCTA causes zero or minimal effect to the his...Continue Reading

References

Jun 1, 1993·Radiology·K D HopperS J Shirk
Oct 5, 2006·Journal of Forensic Sciences·Christian JackowskiMichael J Thali
Apr 24, 2008·AJR. American Journal of Roentgenology·Steffen RossErich Gygax
Jan 6, 2011·International Journal of Legal Medicine·Coraline EggerSilke Grabherr
Jan 11, 2011·Journal of Forensic and Legal Medicine·Chong Zhou, Roger W Byard
Dec 13, 2012·International Journal of Legal Medicine·Claire RobinsonGuy Rutty
Mar 22, 2013·International Journal of Legal Medicine·C BruguierS Grabherr
Jul 13, 2013·Forensic Science, Medicine, and Pathology·Go InokuchiHirotaro Iwase
Mar 1, 2014·Forensic Science, Medicine, and Pathology·R B Dettmeyer
Apr 25, 2014·PloS One·Jonas Christoph ApitzschAndreas H Mahnken
May 14, 2014·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Steffen G RossPatricia M Flach
Apr 7, 2015·La Radiologia medica·Silke GrabherrPatrice Mangin

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Citations

Jan 5, 2018·Forensic Science, Medicine, and Pathology·Ingo von BothJayantha C Herath
Nov 16, 2020·Forensic Science, Medicine, and Pathology·Elizabeth D ParatzSarah Parsons
Feb 3, 2020·Diagnostic and Interventional Imaging·A R J PéportéP M Flach

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