The Effect of Postmastectomy Radiation Therapy on Breast Implants: Material Analysis on Silicone and Polyurethane Prosthesis

Annals of Plastic Surgery
Federico Lo TortoDiego Ribuffo

Abstract

The pathogenic mechanism underlying capsular contracture is still unknown. It is certainly a multifactorial process, resulting from human body reaction, biofilm activation, bacteremic seeding, or silicone exposure. The scope of the present article is to investigate the effect of hypofractionated radiotherapy protocol (2.66 Gy × 16 sessions) both on silicone and polyurethane breast implants. Silicone implants and polyurethane underwent irradiation according to a hypofractionated radiotherapy protocol for the treatment of breast cancer. After irradiation implant shells underwent mechanical, chemical, and microstructural evaluation by means of tensile testing, infrared spectra in attenuated total reflectance mode, nuclear magnetic resonance, and field emission scanning electron microscopy. At superficial analysis, irradiated silicone samples show several visible secondary and tertiary blebs. Polyurethane implants showed an open cell structure, which closely resembles a sponge. Morphological observation of struts from treated polyurethane sample shows a more compact structure, with significantly shorter and thicker struts compared with untreated sample. The infrared spectra in attenuated total reflectance mode spectra of irradiated...Continue Reading

References

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Sep 12, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Diego RibuffoAlberto Rainer
Feb 17, 2017·Plastic and Reconstructive Surgery·Federico Lo TortoDiego Ribuffo
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Sep 25, 2017·Plastic and Reconstructive Surgery·Federico Lo TortoDiego Ribuffo

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Citations

Mar 30, 2021·Technical Innovations & Patient Support in Radiation Oncology·Eduardo de Faria Castro FleuryLeontina Caobianco
Aug 23, 2020·Annals of Plastic Surgery·Donato CasellaDiego Ribuffo

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