Abstract
To determine whether prazosin administration following urethral obstruction (UO) reduces the risk for recurrent urethral obstruction (rUO) or lower urinary tract signs, and to document adverse effects associated with prazosin use in cats. Double-blinded, prospective, interventional study. University teaching hospital. A population of 47 consecutive male cats with UO not associated with urinary tract calculi >2 mm in diameter. Cats were randomized to receive either prazosin (0.25 mg/cat PO q 12 h, n = 27) or placebo (n = 20) for 1 month following UO. Cats were monitored for rUO, severity of lower urinary tract signs, and medication adverse effects during hospitalization and through weekly conversations with the owner during the 1- month study period and once more at 6 months following discharge. There was no difference in the rUO rate among cats that received prazosin or placebo prior to hospital discharge (2/26 (7%) versus 1/19 (5%), P = 1.00), during the 1- month medication period (4/26 (15%) versus 3/18 (17%), P = 0.776), or at 6 months following treatment for UO (7/19 (37%) versus 4/13 (31%), P = 0.811). There was no difference in the severity of lower urinary tract signs reported by the owners at the 1-, 2-, 3-, or 4-week f...Continue Reading
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Citations
Aug 11, 2019·Journal of Veterinary Internal Medicine·Ran NivyMichal Mazaki-Tovi
Aug 20, 2019·Journal of Feline Medicine and Surgery·Margaret R SlaterCamille DeClementi
Feb 25, 2020·Journal of Veterinary Emergency and Critical Care·Elizabeth B Davidow
Jan 29, 2020·Journal of Veterinary Emergency and Critical Care·Katie D MauroKenneth J Drobatz
Feb 24, 2021·Journal of the American Veterinary Medical Association·Erica L ReinekeKenneth J Drobatz
Mar 23, 2021·Journal of Feline Medicine and Surgery·Kayla R HansonAndrew Kj Linklater