The effect of prazosin on outcome in feline urethral obstruction

Journal of Veterinary Emergency and Critical Care
Erica L ReinekeKenneth J Drobatz

Abstract

To determine whether prazosin administration following urethral obstruction (UO) reduces the risk for recurrent urethral obstruction (rUO) or lower urinary tract signs, and to document adverse effects associated with prazosin use in cats. Double-blinded, prospective, interventional study. University teaching hospital. A population of 47 consecutive male cats with UO not associated with urinary tract calculi >2 mm in diameter. Cats were randomized to receive either prazosin (0.25 mg/cat PO q 12 h, n = 27) or placebo (n = 20) for 1 month following UO. Cats were monitored for rUO, severity of lower urinary tract signs, and medication adverse effects during hospitalization and through weekly conversations with the owner during the 1- month study period and once more at 6 months following discharge. There was no difference in the rUO rate among cats that received prazosin or placebo prior to hospital discharge (2/26 (7%) versus 1/19 (5%), P = 1.00), during the 1- month medication period (4/26 (15%) versus 3/18 (17%), P = 0.776), or at 6 months following treatment for UO (7/19 (37%) versus 4/13 (31%), P = 0.811). There was no difference in the severity of lower urinary tract signs reported by the owners at the 1-, 2-, 3-, or 4-week f...Continue Reading

References

Apr 2, 1977·The Veterinary Record·I McLeish
Mar 1, 1985·Clinical Pharmacokinetics·J VincentP C Rubin
Jul 1, 1983·Journal of Cardiovascular Pharmacology·R A BaughmanL Z Benet
Aug 27, 1999·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·R C WeichselbaumJ Holte
Feb 7, 2002·Expert Opinion on Pharmacotherapy·Russell Chess-Williams
Jul 22, 2004·Journal of Feline Medicine and Surgery·D A Gunn-Moore, C M Shenoy
Apr 4, 2006·American Journal of Veterinary Research·Jodi L WestroppC A T Buffington
Aug 28, 2007·Journal of Feline Medicine and Surgery·Bernhard GerberClaudia E Reusch
Dec 15, 2010·Journal of Feline Medicine and Surgery·Gilad SegevEran Lavy
Apr 2, 2011·American Journal of Veterinary Research·Christine H WuJodi L Westropp
Feb 13, 2013·Journal of Feline Medicine and Surgery·Marine HugonnardIsabelle Goy-Thollot
Aug 2, 2013·Journal of the American Veterinary Medical Association·Peter F Hetrick, Elizabeth B Davidow
Oct 8, 2013·Journal of the American Veterinary Medical Association·Beth W EisenbergNicholas J Horton
Oct 19, 2013·Journal of the American Veterinary Medical Association·Jody Lulich, Carl Osborne

❮ Previous
Next ❯

Citations

Aug 20, 2019·Journal of Feline Medicine and Surgery·Margaret R SlaterCamille DeClementi
Jan 29, 2020·Journal of Veterinary Emergency and Critical Care·Katie D MauroKenneth J Drobatz
Feb 24, 2021·Journal of the American Veterinary Medical Association·Erica L ReinekeKenneth J Drobatz
Mar 23, 2021·Journal of Feline Medicine and Surgery·Kayla R HansonAndrew Kj Linklater

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

Related Papers

Journal of Feline Medicine and Surgery
Roswitha DorschKatrin Hartmann
The North American Veterinarian
J K STROCKBINE
Journal of the American Veterinary Medical Association
Jody Lulich, Carl Osborne
© 2022 Meta ULC. All rights reserved