The effect of pre-hospital statins therapy on incidence of in-hospital death and total MACCE in patients with PCI

Journal of Clinical Pharmacy and Therapeutics
M ZhangC-S Ma

Abstract

To investigate the influence of preoperative statin therapy on rate of major adverse cardiac and cerebrovascular events (MACCE) during hospital stay after successful percutaneous coronary intervention (PCI). Review of patients who underwent PCI between June 2003 and September 2005 (n = 3893) at Beijing Anzhen Hospital of Capital University of Medical Science. (Group I, on statins, n = 3361; group II, not on statins, n = 532). To investigate if preoperative statin therapy was independently associated with the reduction in the risk of adverse postoperative outcomes after PCI. Prognostic factors were assessed using Cox multivariate regression analysis to determine if preoperative statin therapy was independently associated with a reduction in the risk of adverse postoperative outcomes. Our study demonstrated that preoperative statin therapy was not associated with a reduction in risk of mortality and overall MACCE during the hospital stay (0.3% vs. 0.4%; 1.4% vs. 1.2%P > 0.05, respectively).Compared with patients not receiving statins therapy, the hazard ratio for mortality in hospital was 0.738 (95% CI, 0.499-1.211, P = 0.229). Preoperative statin therapy did not reduce the risk of mortality and the rates of MACCE during the hosp...Continue Reading

References

Jan 19, 2000·Circulation·D J MaronM F Linton
Nov 14, 2000·The American Journal of Cardiology·M I DotaniC M Gibson
Dec 18, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·S P JonesD J Lefer
Jun 19, 2002·JAMA : the Journal of the American Medical Association·L Kristin NewbyUNKNOWN SYMPHONY and 2nd SYMPHONY Investigators. Sibrafiban vs Aspirin to Yield Maximun Protection From Ischemic Heart Events Post-a
Apr 8, 2003·Drugs·Diederick E Grobbee, Michiel L Bots
Jun 2, 2004·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Su Min ChangNasser M Lakkis
Aug 3, 2005·International Journal of Cardiology·Imtiaz S Ali, Karen J Buth
Mar 7, 2006·The Journal of Thoracic and Cardiovascular Surgery·Harold L Lazar
May 4, 2006·JAMA : the Journal of the American Medical Association·Matthias BrielAlain J Nordmann

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Citations

Jul 28, 2011·The Canadian Journal of Cardiology·Li-qiu YanWei Gao
Jan 18, 2012·Journal of Interventional Cardiology·Jun LuoJiang Li
Mar 8, 2014·European Journal of Clinical Investigation·Gian Marco RosaFabrizio Montecucco
Mar 12, 2009·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Elianna Saidenberg, Alan Tinmouth
Jul 4, 2009·Current Opinion in Cardiology·Stella S Daskalopoulou

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