The effect of pregnancy on paternal skin allograft survival

Science in China. Series C, Life Sciences
ZhangFei ShouJiangHua Chen

Abstract

Elucidation of maternal-fetal tolerance mechanisms clarifies the role of regulatory T cells (Treg) in transplant tolerance. This study aim to investigate the effect of pregnancy on paternal skin allograft survival. Flow cytometry techniques, mixed lymphocytes reaction (MLR), PCR, real-time PCR and skin transplantation were key methods. Treg increased significantly from 4.2% before pregnancy to peak at 6.8% day 8 after pregnancy. Both heme oxygenase-1 (HO-1) and indoleamine 2,3-dioxygenase (IDO) mRNA express high in placenta while low in spleen (P<0.05). Although Treg increased during pregnancy, and splenocytes from the pregnant mice showed lower MLR response toward the paternal stimulator, single time pregnancy showed no significant protective effect on paternal skin allograft survival in the tested condition.

References

Sep 1, 1977·The Journal of Experimental Medicine·R N Smith, A E Powell
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Oct 3, 1953·Nature·R E BILLINGHAMP B MEDAWAR
Feb 6, 2004·Nature Immunology·Varuna R AluvihareAlexander G Betz
Sep 1, 2005·Chemical Immunology and Allergy·Udo R MarkertHans-Joachim Seewald
Dec 17, 2005·European Journal of Immunology·Ana C ZenclussenHans-Dieter Volk
Feb 16, 2006·Seminars in Immunology·Herman WaldmannPaul J Fairchild
Feb 28, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Nicola J MonkStipo Jurcevic
Jul 14, 2006·Springer Seminars in Immunopathology·Ana Claudia Zenclussen
Mar 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Indira Guleria, Mohamed H Sayegh
Oct 26, 2007·Cellular Immunology·Jeffrey L Platt
Nov 6, 2007·Obstetrics and Gynecology·Anne SchumacherAna Claudia Zenclussen
Nov 14, 2007·American Journal of Reproductive Immunology : AJRI·Catharina ThuereAna Claudia Zenclussen
Aug 22, 2008·Immunological Investigations·Joan K Riley
Sep 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Shota EndoToshiyuki Takai

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Citations

Jun 16, 2010·Annals of Dermatology·Na Hyun KwonGyong Moon Kim

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