PMID: 6410416Jun 1, 1983Paper

The effect of prenatal dexamethasone on fetal rat lung prostaglandin synthesis

Prostaglandins, Leukotrienes, and Medicine
M Y TsaiD M Brown

Abstract

[14C]Arachidonic acid conversions were studied in homogenates of lungs from 20, 21, and 22 day fetuses with or without prenatal dexamethasone treatment. The major metabolites were in all cases 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE), 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), prostaglandin E2 (PGE2), and 12-L-hydroxy-5,8,10-heptadecatrienoic acid (HHT). Prostaglandin F2 alpha (PGF2 alpha), prostaglandin D2 (PGD2), and thromboxane B2 (TxB2) were present in small amounts. Dexamethasone treatment significantly stimulated the conversion of [14C]-arachidonic acid in fetal lung homogenates to 6-keto-PGF1 alpha, PGE2, 12-HETE, and HHT, at 20 days gestational age. This effect was dependent on the dose of dexamethasone. These results suggest that dexamethasone accelerates the maturation of the enzymes involved in prostaglandin synthesis. Because dexamethasone is also known to inhibit phospholipase A2, further studies are required to determine the overall in vivo effect of prenatal dexamethasone therapy on fetal lung prostaglandin synthesis.

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Aug 18, 1982·Biochimica Et Biophysica Acta·M Y TsaiD M Brown

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Citations

Jul 1, 1986·Prostaglandins, Leukotrienes, and Medicine·D DuvalF Homo-Delarche
Oct 24, 1998·Prostaglandins & Other Lipid Mediators·H JohnW Schlegel
Apr 18, 2007·Molecular and Cellular Biology·Alysia Kern LovgrenBeverly H Koller
Aug 23, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Y KawanoI Miyakawa
Mar 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·H SinzingerP Fitscha
Jan 1, 1985·British Journal of Obstetrics and Gynaecology·M Cvetkovic, O Ylikorkala
Feb 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·N Naveh, C Weissman
Feb 12, 1998·The American Journal of Physiology·J S TordayJ Qin
Feb 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D Duval, M Freyss-Beguin

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