PMID: 6411118Jul 1, 1983Paper

The effect of prenatal protein-energy malnutrition on the development of mandibles and long bones in newborn rats

The British Journal of Nutrition
T NakamotoM M Winkler

Abstract

To evaluate the role of gestational protein-energy malnutrition on fetal hard-tissue growth and metabolism, we measured several variables in the growth centres of mandibles and long bones of newborn rats. Control pups and pups of malnourished dams had approximately the same extent of reduction in body-weight, mandibular weight and long-bone weight. The malnourished group had more cells in the mandible although cell size was the same as that of controls. In contrast, in the long bones, the malnourished group had fewer cells than did controls whereas cell size was unchanged. Calcium content was the same in long bones of both groups, but was less in the mandibles of pups from malnourished dams. Ca metabolism as measured by 45Ca uptake was unchanged in the long bones, but was increased in the mandibles of the malnourished group shortly after birth. Calcification patterns at birth in these bones correlated well with alkaline phosphatase (EC 3.1.3.1) activity. These findings indicate that the mandibles and long bones of offspring are affected differently by protein-energy malnutrition during the mother's gestation. Prenatal nutritional stress resulted in a disturbance of the pituitary-adrenal system. Increased adrenal corticosterone ...Continue Reading

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Citations

Jul 16, 2013·Archives of Oral Biology·K N Ferraz-PereiraR Manhães-de-Castro
Oct 22, 2011·Forensic Science International : Synergy·Sumit T PatilN Y Kamdi
May 29, 2015·Journal of Applied Oral Science : Revista FOB·Marcelo Arthur CavalliEdson Aparecido Liberti
Jan 1, 1993·Paediatric and Perinatal Epidemiology·C CorchiaM Orzalesi
Mar 1, 1997·Zentralblatt für Veterinärmedizin. Reihe A·P GuilloteauJ W Blum
Oct 27, 2020·Journal of Oral Biology and Craniofacial Research·Bruno CalsaMilton Santamaria

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