The effect of pretreatment with terpenes on transdermal iontophoretic delivery of arginine vasopressin

Il Farmaco
Vinod B Nair, Ramesh Panchagnula

Abstract

This study investigates the effects of terpenes and iontophoresis on the in vitro permeation of arginine vasopressin (AVP) through rat skin and the biophysical changes induced by the chemical enhancers in the stratum corneum (SC) lipids by FT-IR spectroscopy. Pretreatment with terpenes (e.g. 5% w/v, carvone, pulegone, cineole and menthol in EtOH:W (2:1) system) increased (P < 0.05) the flux of AVP in comparison to control (not pretreated with enhancer) but was not significantly different (P > 0.05) in comparison to iontophoresis. Amongst different terpenes studied maximum enhancement ratio was observed with cineole. In combination, iontophoresis did not further increase (P > 0.05) the permeation of AVP through the enhancer pretreated epidermis in comparison to pretreatment with enhancer or iontophoresis alone. Hence it was concluded that although the combination was effective in flux enhancement compared to control, there was no synergism in action between terpenes and iontophoresis. FT-IR spectroscopic studies revealed that EtOH:W (2:1) system is not effective in lipid extraction. The area under the symmetric and asymmetric stretching peaks at 2850 and 2920 cm(-1) revealed that at the concentration used terpenes did not extrac...Continue Reading

References

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Citations

Jan 20, 2007·AAPS PharmSciTech·Işik Sarigüllü OzgüneyGökhan Ertan
Aug 1, 2011·Drug Delivery and Translational Research·Sanyog JainNitin K Swarnakar
Oct 1, 2011·Drug Delivery and Translational Research·Sanyog JainNitin K Swarnakar
Oct 16, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Amit AlexanderDulal Krishna Tripathi
Jul 1, 2006·International Journal of Pharmaceutics·A Femenía-FontA López-Castellano
Dec 6, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sérgio M C SilvaBozena B Michniak-Kohn

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