The effect of prolonged tracheal intubation on the association between patent ductus arteriosus and bronchopulmonary dysplasia (grades 2 and 3).

Journal of Perinatology : Official Journal of the California Perinatal Association
Ronald Clyman, Nancy K Hills

Abstract

To determine if the need for mechanical ventilation alters the association between prolonged patent ductus arteriosus (PDA) exposure and bronchopulmonary dysplasia (grades 2 and 3) (BPD). Observational study of 407 infants (<28 weeks' gestation) with echocardiograms performed at planned intervals. Twelve percent (48/407) of study infants had BPD (grades 2 and 3). In a multivariable regression model, exposure to a moderate-to-large PDA shunt for ≥7 days was associated with an increased risk of BPD (grades 2 and 3) (from 16 to 35%: aRD = 19% (6, 32%), p < 0.005) when infants required ≥10 days of intubation (n = 170). In contrast, there was no significant association between prolonged PDA exposure and BPD when infants required ≤9 days of intubation (aRD = 4%) (-1, 10%) (n = 237). Moderate-to-large PDAs are associated with an increased risk of BPD-but only when infants require intubation ≥10 days.

References

Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·A H Jobe, E Bancalari
Jun 14, 2003·The Cochrane Database of Systematic Reviews·L CookeP Woodgate
Nov 3, 2004·Pediatrics·Michele C WalshUNKNOWN National Institute of Child Health and Human Development Neonatal Research Network
Aug 23, 2005·Archives of Disease in Childhood. Fetal and Neonatal Edition·M El HajjarL Storme
Dec 3, 2005·Pediatrics·Richard A EhrenkranzUNKNOWN National Institutes of Child Health and Human Development Neonatal Research Network
Feb 26, 2010·Journal of Perinatology : Official Journal of the California Perinatal Association·W E Benitz
Jul 9, 2010·The Cochrane Database of Systematic Reviews·Peter W FowlieWilliam McGuire
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Matthew M LaughonUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Jul 8, 2011·The Cochrane Database of Systematic Reviews·Arne Ohlsson, Sachin S Shah
Jul 31, 2013·Archives of Disease in Childhood. Fetal and Neonatal Edition·Anna SellmerTine Brink Henriksen
Mar 19, 2014·The Journal of Pediatrics·Ronald I ClymanUNKNOWN Patent Ductus Arteriosus Ligation/Hypotension Trial Investigators
Apr 18, 2015·The Journal of Pediatrics·Federico SchenaMonica Fumagalli
Jun 19, 2015·American Journal of Perinatology·Melissa C Liebowitz, Ronald I Clyman
Sep 24, 2015·Annals of the American Thoracic Society·Brenda B PoindexterUNKNOWN Prematurity and Respiratory Outcomes Program
Oct 21, 2018·The Journal of Pediatrics·Ronald I ClymanUNKNOWN PDA-TOLERATE (PDA: TO LEave it alone or Respond And Treat Early) Trial Investigators
Apr 18, 2019·American Journal of Respiratory and Critical Care Medicine·Erik A JensenSara B DeMauro
Sep 27, 2019·Journal of Perinatology : Official Journal of the California Perinatal Association·Hussnain MirzaRajan Wadhawan

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Citations

Nov 2, 2020·The Journal of Pediatrics·William E Benitz, Valerie Y Chock
Apr 2, 2021·Pediatric Research·Ronald I ClymanJean Christophe Rozé
Oct 16, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Craig R WheelerPhilip T Levy

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