The effect of prolonged treatment with imipramine on the biosynthesis and functional characteristics of D2 dopamine receptors in the rat caudate putamen

British Journal of Pharmacology
M Dziedzicka-Wasylewska, R Rogoz

Abstract

1. The present study shows the effects of imipramine in a single dose (10 mg kg(-1), p.o.) or following repeated (14 days, twice a day) treatment on the level of mRNA coding for D2 dopamine receptors in the rat caudate putamen (CP). Repeated administration of imipramine resulted in the increase of the level of mRNA coding for D2 dopamine receptors. 2. Radioligand binding studies with the D2 receptor agonist, [3H]-N-0437, indicated, that following imipramine administration, the affinity of the agonist for the D2 dopamine receptor significantly increased, though without any alterations in the Bmax. 3. Pharmacological manipulations (by use of forskolin, GppNHp and quinpirole) of the cyclic AMP generating system, ex vivo following administration of imipramine indicated that an up-regulation of factors inhibiting cyclic GMP formation takes place. 4. Most probably it is the D2 dopamine receptor which undergoes functional up-regulation, resulting from the enhancement of its biosynthesis.

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Citations

Sep 11, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Charles E Dean
Sep 19, 2012·Journal of Pharmacological Sciences·Naohito TokunagaMasahiro Nomoto
May 1, 2002·Behavioural Pharmacology·M Dziedzicka-WasylewskaJ Maj
Mar 24, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marta Dziedzicka-WasylewskaHeinz Bönisch

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