The effect of propafenone on premature ventricular contractions (PVC): an analysis based on heart rate dependency of PVCs

Japanese Heart Journal
T SaikawaT Sakata

Abstract

The effect of 450 mg/day propafenone for two weeks on premature ventricular contractions (PVCs) was studied in combination with an assessment of heart rate (HR) dependency of PVCs using Holter ECG monitoring in patients with more than 720 PVCs per day. The PVC-HR correlation was classified into positive (P), bidirectional (B), and flat and negative (FN) correlation groups. The positive group included only patients in whom PVC frequency increased with a heart rate increase, while the bidirectional group included patients with PVCs whose frequency increased at low heart rates and decreased at high heart rates. The FN group contained both flat (PVC frequency was almost fixed regardless of heart rate changes) and negative (PVC frequency decreased as heart rate increased) correlations. The effectiveness of propafenone was 70% in the positive group and 50% in the nonpositive group which included both bidirectional (67%) and FN (0%) groups, using a > 70% PVC reduction as a criterion of efficacy. From this, we concluded that propafenone is effective in patients showing either positive or bidirectional PVC-HR correlation. The coupling interval (CI) of PVCs was also prolonged by propafenone as a whole. The present study suggests that the...Continue Reading

References

May 1, 1977·Progress in Cardiovascular Diseases·G R Ferrier
Oct 15, 1992·The American Journal of Cardiology·F LombardiE Cappiello
Apr 1, 1991·American Heart Journal·M HernandezP R Kowey
Jun 1, 1990·Cardiovascular Drugs and Therapy·V SantinelliM Condorelli
Feb 22, 1990·The New England Journal of Medicine·C Funck-BrentanoD M Roden
Jan 1, 1986·Journal of Electrocardiology·M ItoK Yamada
Jun 1, 1985·Journal of the American College of Cardiology·D A ChilsonE N Prystowsky
Apr 1, 1984·Journal of Clinical Pharmacology·E M Vaughan Williams
Mar 1, 1984·European Heart Journal·A J Camm, R S Bexton

❮ Previous
Next ❯

Citations

Jun 15, 2014·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Parin J PatelMathew D Hutchinson
Jun 27, 2007·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Gregory EngelVictor F Froelicher

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.