The effect of prophylactic topical carbonic anhydrase inhibitors in canine primary closed-angle glaucoma

The Journal of Small Animal Practice
R StavinohovaC Busse

Abstract

To determine the effect of 1% brinzolamide, 2% dorzolamide hydrochloride or combination 2% dorzolamide hydrochloride/0 · 5% timolol to delay the elevation of the intraocular pressure in second eyes of dogs with primary closed-angle glaucoma. Analysis of retrospectively collated data from 40 dogs with primary closed-angle glaucoma, where the non-affected eye was treated prophylactically with brinzolamide (n = 10), dorzolamide (n = 18) or combination dorzolamide/timolol therapy (n = 12). The 40 treated dogs (median age of 76 · 2 months) comprised 25 females/15 males, 19 entire/21 neutered. Twenty dogs developed glaucoma in the contralateral eye (median time of 9 · 2 months). No statistically significant difference was identified during treatment failure between the treatment groups (P = 0 · 66). The second eye remained normotensive in 20 dogs; four dogs until the conclusion of the study (median: 27 · 0 months), three dogs until death (median: 15 · 4 months), seven dogs until lost to follow-up (median: 11 · 6 months). Out of these 20 dogs, treatment was discontinued because of lack of owner compliance in two dogs and following a local drug reaction in four dogs (median: 8 · 9 months). There was no evidence that the tested drugs de...Continue Reading

References

Jun 1, 1979·Acta Ophthalmologica·N V Nielsen, J S Eriksen
May 1, 1990·The Veterinary Clinics of North America. Small Animal Practice·D E Brooks
Apr 28, 1999·American Journal of Ophthalmology·A KonowalR J Epstein
Dec 28, 1999·American Journal of Ophthalmology·I Adamsons
Dec 30, 1999·Progress in Retinal and Eye Research·M F Sugrue
Sep 21, 2000·Journal of the American Animal Hospital Association·P E MillerM K Herrmann
Apr 10, 2002·Veterinary Ophthalmology·A Michelle WillisTerah E Robbin

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