PMID: 4291385Nov 1, 1966Paper

The effect of propranalol on the calorigenic response in brown adipose tissue of new-born rabbits to catecholamines, glucagon, corticotrophin and cold exposure

The Journal of Physiology
T Heim, D Hull

Abstract

1. Experiments measuring the rate of oxygen consumption of unanaesthetized new-born rabbits and the blood flow in brown adipose tissue of anaesthetized new-born rabbits are described.2. The increase in rate of oxygen consumption caused by I.V. infusion of noradrenaline, adrenaline and isoprenaline (2 mug/kg.min for 10 min) was blocked by propranalol (I.V. 1 mg/kg) but the increase caused by cold exposure was not. A larger dose of propranalol (5 mg) blocked the calorigenic response to cold exposure as well.3. Infusion of glucagon (I.V. 4 mug/kg.min for 10 min) caused a large increase in the rate of the rabbit's oxygen consumption and in blood flow through its brown adipose tissue. These responses, which reached a maximum within 10 min from the start of the infusion, were not blocked by propranalol (1 or 5 mg/kg).4. Infusion of corticotrophin (I.V. 1 i.u./kg.min for 10 min) also caused a large increase in the rate of oxygen consumption of new-born rabbits. The response reached a maximum about 20 min from the start of the infusion and it was not blocked by propranalol (5 mg/kg).5. These results support the conclusion that noradrenaline is released at sympathetic endings in brown adipose tissue and that the increase in blood flow c...Continue Reading

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