The effect of propranolol on the serotonin concentration in the portal plasma after vagal nerve stimulation in the cat

Acta Physiologica Scandinavica
G PetterssonJ K Siepler

Abstract

Efferent cervical vagal nerve stimulation in the cat caused a marked increase of the portal plasma 5-HT concentration. This increase was more than two-fold within 15 min of stimulation. After cessation of stimulation portal plasma 5-HT returned to basal levels within 10 min. Treatment with the beta-adrenoceptor antagonist propranolol, in various doses (0.1-2 mg/kg b.wt.), did not abolish but significantly reduced the response to vagal stimulation, particularly during the final part of the stimulation period. The results confirm the existence of a beta-adrenoceptor-mediated release of 5-HT, but also suggest that other mechanisms for 5-HT release may be involved in the response on vagal nerve stimulation.

References

Aug 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·H SchwörerH Kilbinger
Apr 1, 1987·Cell and Tissue Research·O NilssonL E Ericson
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y CetinW G Forssmann
Oct 19, 1999·Cephalalgia : an International Journal of Headache·G A LambertA S Zagami
Dec 1, 1983·Journal of Autonomic Pharmacology·E Adler-Graschinsky

Citations

Mar 1, 1979·Acta Physiologica Scandinavica·B NewsonL M Nyhus
Jul 1, 1976·Acta Physiologica Scandinavica·H AhlmanJ Lundberg
Nov 1, 1976·Acta Physiologica Scandinavica·H AhlmanJ Kewenter
Jan 1, 1975·Histochemistry·A G Pearse, J M Polak
May 1, 1969·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A G Pearse
Jan 1, 1974·Cell and Tissue Research·H Ahlman, L Enerbäck
Jan 1, 1974·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·A G PearseJ C Brown
Jan 1, 1971·Journal of Pharmaceutical Sciences·M F TansyF J Hohenleitner
Sep 1, 1968·Japanese Journal of Pharmacology·T MuryobayashiK Shimamoto
Mar 1, 1971·Journal of Pharmaceutical Sciences·F J HohenleitnerR H Golder
Jun 1, 1957·The Journal of Experimental Medicine·E P BENDITT, R L WONG

Related Concepts

Serotonin Measurement
Vagal Stimulation
Serotonin
Antagonist Muscle Action
Vagus Nerve Structure
Adrenergic Receptor
Neck
Propranolol
Rexigen
Motor Pathways

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.