PMID: 679503Jul 1, 1978Paper

The effect of propranolol on thyroid hormones and oxygen consumption in thyrotoxicosis

Clinical Endocrinology
J SaundersP H Sönksen


The possibility that propranolol may exert its beneficial actions in thyrotoxicosis by an effect on thyroid hormone concentrations has been investigated by measuring these and oxygen consumption in a group of thyrotoxic patients before and after treatment with propranolol. Following treatment a significant fall in plasma T3 concentration and oxygen consumption occurred and a direct correlation was found between these two variables. Propranolol may, therefore, exert some of its beneficial effects in thyrotoxicosis by an action on T3 metabolism.


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