PMID: 8953922Nov 1, 1996Paper

The effect of prostaglandin E1 on choleresis in the rat liver after relief of biliary obstruction

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
T Ikeda

Abstract

The effect of prostaglandin E1 on bile excretion was investigated using the ex vivo perfused rat liver. In the control group (normal liver), the perfusion system was stabilized 60 minutes after the induction of the perfusion and the effect of administered prostaglandin E1 was most markedly observed at the concentration of 2.5 micrograms/l. The effects of prostaglandin E1 on the liver with biliary obstruction was investigated on 14 days after the induction of biliary obstruction when the obstruction was spontaneously resolved by recanalization of the obstructed bile duct. Both portal blood flow and bile excretion increased significantly in the PGE1 (+) group, perfused with perfusate containing 2.5 micrograms/l of prostaglandin E1, compared to the PGE1 (-) group. However, there was no significant difference between the PGE1 (+) and the PGE1 (-) in excretion of total bile acid. The c-AMP level of perfusate increased by the administration of prostaglandin E1. It was concluded that prostaglandin E1 increased portal blood flow and bile acid-independent bile flow in the liver after relief of biliary obstruction.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.