The effect of protease inhibitor therapy on growth and body composition in human immunodeficiency virus type 1-infected children

Pediatrics
Tracie L MillerS L Gorbach

Abstract

To determine the effect of protease inhibitors (PIs) on growth and body composition in children with human immunodeficiency virus type 1 (HIV-1) infection. HIV-1-infected children have chronic problems with both linear growth and weight gain. Viral load may directly influence growth and nutritional status of HIV-1-infected children with reduction of viral load improving the nutritional condition. Data from 67 patients who initiated PI therapy between 1996 and 1999 and who were enrolled in a prospective, longitudinal study of growth and nutrition in HIV-1-infected children were analyzed. Outcomes included pre-PI versus post-PI measures of height, weight, weight-for-height, triceps skinfold thickness, and arm muscle circumference. Predictor covariates included age, race, gender, Tanner stage, CD4 z score, Centers for Disease Control and Prevention stage, route of infection, plasma HIV-1 RNA, other antiretroviral therapy, recommended daily allowances for calories, treatment with megestrol acetate, and PI therapy. Sixty-seven children were followed for a median of 2.4 years with a total of 362 visits (median: 5 visits; range: 1-12). During follow-up, they received PIs for a median of 5 months. Fifty-one percent were girls, 54% blac...Continue Reading

Citations

Mar 26, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Judith NeradMarcy Fenton
Apr 23, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kunjal PatelUNKNOWN Pediatric AIDS Clinical Trials Group 219/219C Study Team
Oct 16, 2009·AIDS Patient Care and STDs·Suad KapetanovicUNKNOWN Pediatric AIDS Clinical Trials
Apr 4, 2002·Journal of Pediatric Gastroenterology and Nutrition·Tracie L Miller
Dec 23, 2003·The Pediatric Infectious Disease Journal·Caroline J ChantryUNKNOWN Pediatric AIDS Clinical Trials Group Protocol 152 Study Team
Apr 9, 2005·The Pediatric Infectious Disease Journal·Sharon A NachmanUNKNOWN Pediatric AIDS Clinical Trials Group 377 Study Team
Jan 2, 2007·The Pediatric Infectious Disease Journal·Caroline J ChantryJack Moye
Apr 7, 2007·The Pediatric Infectious Disease Journal·Sara GuillénMaría Angeles Muñoz
Sep 1, 2005·Journal of Pediatric Gastroenterology and Nutrition·Denise L JacobsonTracie L Miller
Jun 10, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Tracie L MillerSteven E Lipshultz
Nov 7, 2009·JPEN. Journal of Parenteral and Enteral Nutrition·Nasim SaberyUNKNOWN American Society for Parenteral and Enteral Nutrition Board of Directors
Feb 24, 2007·Journal of Pediatric Endocrinology & Metabolism : JPEM·Roy J KimRichard M Rutstein
Dec 23, 2004·Paediatric Drugs·Alfredo GuarinoVittoria Buccigrossi
Apr 9, 2014·Journal of Pediatric Gastroenterology and Nutrition·Lori E ArbeitmanTracie L Miller
Aug 30, 2014·Endocrinology and Metabolism Clinics of North America·Lindsey A Loomba-AlbrechtCaroline J Chantry
Jun 13, 2009·Nutrition Reviews·Sheila IsanakaWafaie W Fawzi
Nov 14, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Winstone M NyandikoWilliam M Tierney
Jul 11, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Caroline J ChantryUNKNOWN PACTG 1010 Team
Jun 7, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kate BuchaczUNKNOWN Pediatric AIDS Clinical Trials Group 219 Study Team
Jul 31, 2008·Journal of Pediatric Gastroenterology and Nutrition·Tracie L MillerUNKNOWN HIV Working Group
Jun 10, 2008·The Journal of Pediatrics·Tracie L MillerAbby Shevitz
Jan 2, 2007·International Journal of Antimicrobial Agents·Raffaella RossoAndrea De Maria
Sep 11, 2007·Maternal & Child Nutrition·Michael K HendricksLesley T Bourne
May 6, 2008·Journal of the Cardiometabolic Syndrome·Tracie L MillerSteven E Lipshultz
Apr 3, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M TrigueiroK L Ortega
Oct 18, 2005·The Journal of Pediatrics·Geoffrey A Weinberg, Nicholas Jospe
Aug 30, 2005·Advances in Pediatrics·Michael T Brady
Apr 12, 2015·Médecine et maladies infectieuses·J Jesson, V Leroy
Feb 26, 2016·Tropical Medicine & International Health : TM & IH·Ute D FeuchtMariana Kruger
Jul 9, 2011·Revista Da Sociedade Brasileira De Medicina Tropical·Marina Hjertquist TremeschinJacqueline Pontes Monteiro
Jun 20, 2003·European Journal of Clinical Investigation·S ResinoMa A Muñoz-Fernández
Jul 11, 2003·AIDS·Gwenda VerweelGareth Tudor-Williams

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