The effect of protease inhibitors derived from potato formulated in a minidrink on appetite, food intake and plasma cholecystokinin levels in humans

International Journal of Obesity : Journal of the International Association for the Study of Obesity
H P F PetersS A Wiseman

Abstract

Protease inhibitor 2 derived from potato (PI2) is claimed to reduce appetite and food intake, stimulate the satiety hormone cholecystokinin (CCK) and lower postprandial glucose peaks when taken before a meal. However, current literature is inconclusive with regard to its efficacy and mechanism. Furthermore, the potential effect of PI2 on appetite motivational ratings without an immediately following meal has not previously been reported. To comprehensively test the effects of 30 mg PI2 in a minidrink on appetite ratings, subsequent food intake, and plasma CCK and glucose responses. Minidrinks with or without 30 mg PI2 were compared in three separate substudies (A, B and C), each using a two-way, placebo-controlled, balanced-order, cross-over design and 23 or 24 subjects (mean over groups: body mass index 25.0 kg m(-2), range 22.5-30.7 kg m(-2); age 41.3, range 18-62 years). The minidrink was given (A) 120 or (B) 30 min before an ad libitum lunch or (C) 30 min before a fixed lunch. Study parameters were self-reported satiety (substudies A and C), ad libitum meal intake (substudies A and B), and (in an n=12 subset) plasma CCK and blood glucose in all substudies. All results were analyzed using analysis of covariance. Protease-inh...Continue Reading

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Citations

Sep 21, 2013·European Journal of Clinical Nutrition·L MarcianiR C Spiller
Aug 27, 2013·European Journal of Nutrition·Harry P F PetersSergey M Melnikov
Aug 2, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H P F PetersD J Mela
Jan 31, 2012·Tropical Animal Health and Production·Brigitte L MaassMichael Peters
May 16, 2013·Advances in Nutrition·G Harvey AndersonChristopher E Smith
Mar 8, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Jennifer J LeeNick Bellissimo
Jun 28, 2016·Experimental and Therapeutic Medicine·Sae Kwang KuJoo Wan Kim
Mar 13, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Marion Flechtner-MorsUwe Schumann
Jun 23, 2020·Food Science & Nutrition·Xue WangShi-Long Jiang
Jun 11, 2021·BMC Plant Biology·Nikhilesh K YadavAshok P Giri

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