PMID: 6171262Mar 15, 1981Paper

The effect of protein depletion and repletion on muscle-protein turnover in the chick

The Biochemical Journal
M L MacDonald, R W Swick

Abstract

Rates of growth and protein turnover in the breast muscle of young chicks were measured in order to assess the roles of protein synthesis and degradation in the regulation of muscle mass. Rates of protein synthesis were measured in vivo by injecting a massive dose of L-[1-14C]valine, and rates of protein degradation were estimated as the difference between the synthesis rate and the growth rate of muscle protein. In chicks fed on a control diet for up to 7 weeks of age, the fractional rate of synthesis decreased from 1 to 2 weeks of age and then changed insignificantly from 2 to 7 weeks of age, whereas DNA activity was constant for 1 to 7 weeks. When 4-week-old chicks were fed on a protein-free diet for 17 days, the total amount of breast-muscle protein synthesized and degraded per day and the amount of protein synthesized per unit of DNA decreased. Protein was lost owing to a greater decrease in the rate of protein synthesis, as a result of the loss of RNA and a lowered RNA activity. When depleted chicks were re-fed the control diet, rapid growth was achieved by a doubling of the fractional synthesis rate by 2 days. Initially, this was a result of increased RNA activity; by 5 days, the RNA/DNA ratio also increased. There was n...Continue Reading

Citations

Sep 1, 1987·British Poultry Science·T MuramatsuJ Okumura
Jul 1, 1985·The British Journal of Nutrition·T MuramatsuM E Coates
Jul 1, 1987·The British Journal of Nutrition·D Attaix, M Arnal
Jun 1, 1996·The British Journal of Nutrition·S TesseraudA M Chagneau
Nov 1, 1988·The British Journal of Nutrition·Y PinchasovZ Nitsan
Jan 1, 1982·Critical Reviews in Food Science and Nutrition·R W Swick
May 25, 1983·Biochimica Et Biophysica Acta·J G Brown, D J Millward
Aug 6, 1986·Biochimica Et Biophysica Acta·K HayashiV R Young
Jul 16, 1986·Biochimica Et Biophysica Acta·D AttaixM Arnal

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