The effect of protein intake and resistance training on muscle mass in acutely ill old medical patients - A randomized controlled trial

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Sussi F BuhlJanne Petersen

Abstract

Stress metabolism is associated with accelerated loss of muscle that has large consequences for the old medical patient. The aim of this study was to investigate if an intervention combining protein and resistance training was more effective in counteracting loss of muscle than standard care. Secondary outcomes were changes in muscle strength, functional ability and body weight. 29 acutely admitted old (>65 years) patients were randomly assigned to the intervention (n = 14) or to standard care (n = 15). The Intervention Group received 1.7 g protein/kg/day during admission and a daily protein supplement (18.8 g protein) and resistance training 3 times per week the 12 weeks following discharge. Muscle mass was assessed by Dual-energy X-ray Absorptiometry. Muscle strength was assessed by Hand Grip Strength and Chair Stand Test. Functional ability was assessed by the de Morton Mobility Index, the Functional Recovery Score and the New Mobility Score. Changes in outcomes from time of admission to three-months after discharge were analysed by linear regression analysis. The intention-to-treat analysis showed no significant effect of the intervention on lean mass (unadjusted: β-coefficient = -1.28 P = 0.32, adjusted for gender: β-coeff...Continue Reading

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Citations

Jun 9, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Keisuke MaedaHiroshi Shamoto
Jan 19, 2019·Physiotherapy Research International : the Journal for Researchers and Clinicians in Physical Therapy·Morten Tange KristensenThomas Linding Jakobsen
May 24, 2019·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·B D StephensenS R Smith
Apr 8, 2017·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Robert G MartindaleStephen A McClave
Dec 30, 2015·PeerJ·Mette Merete PedersenThomas Bandholm

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