PMID: 2100829Jan 1, 1990Paper

The effect of protein restriction on the severity and recovery from ischemic renal failure

Renal Failure
A C SeguroA S Rocha

Abstract

The effects of chronic dietary protein restriction on ischemic renal failure were evaluated in rats subjected to 90 min of bilateral renal clamping. The rats were kept on either 20% casein (regular) diet or casein-free (protein-free) diet 10 days before and 21 days after renal injury. Rats on regular protein diet showed higher levels of BUN and serum creatinine and had a lower inulin clearance (microliter/min/100 g BW) than animals on protein-free diet (289 +/- 34 vs 582 +/- 103, p less than 0.05) 2 days after ischemia. However, the inulin clearance measured 21 days following ischemia was significantly higher in rats on regular diet (1468 +/- 181) than those maintained on protein-free diet after ischemia (560 +/- 167). When unilateral 90 min ischemia was performed in rats on regular diet, the postischemic kidneys showed an incomplete recovery of the inulin clearance (226 +/- 35) compared to the contralateral kidney (900 +/- 116), 21 days after ischemia; whereas in rats on a protein-free diet the inulin clearance averaged 106 +/- 17 in the postischemic kidney and 345 +/- 41 in the right kidney. When left renal ischemia and contralateral nephrectomy were performed, the inulin clearance was 1149 +/- 74 in rats on regular diet and ...Continue Reading

References

Apr 1, 1986·Kidney International·P M ter WeeA J Donker
May 1, 1986·Kidney International·P A LucasG A Coles
Mar 1, 1985·Kidney International·L C RacusenK Solez
Sep 1, 1973·Kidney International·L RabinowitzE H Avery
Nov 1, 1969·Archives of Surgery·D W Wilmore, S J Dudrick
Dec 1, 1983·The American Journal of Medicine·J P BoschS Glabman
Nov 1, 1983·Kidney International·R A Zager, M A Venkatachalam
May 1, 1980·The Journal of Clinical Investigation·I IchikawaB M Brenner

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