PMID: 6220984Jan 1, 1983Paper

The effect of PS-K, a protein bound polysaccharide, on immune responses against allogeneic antigens

International Journal of Immunopharmacology
M J EhrkeE Mihich

Abstract

A single dose of PS-K administered to C57B1/6J mice after immunization augmented both the humoral and cellular allogeneic responses against P815 tumor cells. PS-K addition to primary alloantigen sensitization cultures (C57B1/6J spleen cells against X-irradiated P815 cells) resulted in augmented 3H-thymidine uptake and cell mediated cytolytic activity. Ten daily administrations of PS-K to DBA/2J mice after implantation of a mammary tumor of DBA/2HaDD origin results in increased tumor regression and prolonged survival of the mice. PS-K addition to human mixed lymphocyte cultures caused an augmentation of both cell mediated cytolytic activity and 3H thymidine uptake. The dose dependence of the PS-K effects were described by a bell shaped curve and PS-K did not appear to affect the day of peak development of the various responses. The effects were consistently greater if PS-K was administered at the same time or after antigen presentation. Thus, the immunoaugmenting effects induced by PS-K were similar in each model system tested.

Citations

Jan 1, 1991·Cancer Immunology, Immunotherapy : CII·E YefenofE Klein
Nov 14, 1997·Cancer Immunology, Immunotherapy : CII·K OgoshiK Tsuji
Jan 1, 1988·International Journal of Immunopharmacology·M IkuzawaT Wada
Aug 1, 1993·International Journal of Immunopharmacology·R HiraiK Nomoto

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