The effect of psychological stress on iron absorption in rats.

BMC Gastroenterology
Jianbo ChenMin Li

Abstract

Psychological stress (PS) is recognized as an important pathogenic factor which leads to metabolism disorder in many diseases. Previous studies have shown that systemic iron homeostasis in mammalians was changed under specific stress conditions. In present study, we used communication box to create psychological stress model and investigated the iron apparent absorption, iron accumulation in the apical poles of villous enterocytes and protein expressions of ferroportin 1 (FPN1), ferritin, divalent metal transporter 1 (DMT1). Our study showed that iron apparent absorption decreased and iron significantly accumulated in the apical poles of villous enterocytes in 3 d and 7 d PS groups. The expression of intestinal FPN1 in 3 d and 7 d PS groups was lower than that of control, while the change of intestinal ferritin was opposite. However, the expression of DMT1 did not change. These results demonstrate that PS can decrease iron absorption in rats, which might be related to regulation expression of iron transporters.

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Citations

Apr 9, 2013·Archives of Environmental Contamination and Toxicology·Aneta SalińskaEwa Oleńska
Apr 3, 2013·Biological Trace Element Research·Barbara VanaelstStefaan De Henauw
Nov 29, 2013·Journal of Cellular and Molecular Medicine·Sanja VignjevićGordana Jovčić
Oct 11, 2014·Journal of the American College of Nutrition·Little Flower AugustineShahnaz Vazir
Mar 21, 2017·Canadian Journal of Physiology and Pharmacology·Shaimaa Nasr AminSherif Sabry Hassan
Jul 31, 2019·Animals : an Open Access Journal From MDPI·Marta MontilloSilvana Mattiello
Dec 18, 2012·Journal of Perinatal Medicine·Rinat Armony-SivanEyal Anteby
Sep 16, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Charles L Raison, Andrew H Miller
May 10, 2019·Frontiers in Psychiatry·Lindsay T McDonaldAmanda C LaRue
Nov 11, 2019·Biological Trace Element Research·Shihui GuoWenqiang Ma
Jan 9, 2020·Free Radical Biology & Medicine·Jelena Korać JačićJelena Bogdanović Pristov

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Methods Mentioned

BETA
ELISA
electrophoresis

Software Mentioned

BandScan

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