The effect of pulmonary surfactant on the in vitro activity of Iclaprim against common respiratory bacterial pathogens

Diagnostic Microbiology and Infectious Disease
David B HuangThomas M File

Abstract

The in vitro antimicrobial activity of iclaprim, a novel diaminopyrimidine, against common respiratory bacteria remained unchanged in the presence of pulmonary surfactant (Survanta®) at concentrations that greatly antagonized the antimicrobial activity of daptomycin. These results indicate that iclaprim could be a potential treatment for pneumonia caused by susceptible and multidrug resistant bacteria.

References

Nov 14, 1998·Biochimica Et Biophysica Acta·J Goerke
Nov 19, 2003·Bioorganic & Medicinal Chemistry Letters·Peter SchneiderKhalid Islam
May 18, 2005·The Journal of Infectious Diseases·Jared A SilvermanJeff Alder
Dec 9, 2008·The Journal of Antimicrobial Chemotherapy·I MorrisseyS Hawser
Mar 18, 2009·Antimicrobial Agents and Chemotherapy·Helio S SaderRonald N Jones
Aug 5, 2009·Antimicrobial Agents and Chemotherapy·Heike LaueStephen Hawser
Nov 20, 2016·Diagnostic Microbiology and Infectious Disease·Robert A GiacobbePatricia A Bradford

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.