PMID: 7580753Jul 1, 1995Paper

The effect of pyrimidines, levamisole and prodigiozan on the antigen-specific regulation of delayed hypersensitivity in relation to the age and strain of the mice

Eksperimental'naia i klinicheskaia farmakologiia
D T GaĭnutdinovaV V Speranskiĭ

Abstract

The effect of pyrimidine, levamizol, and prodigiozan on the retarded hypersensitivity (RH) was studied on a model of adoptive transfer of the splenocytes from donors of different ages to young syngeneic recipients. Splenocytes from CBA and BALB/c suckers, receiving pyrimidine, activate the RH suppression. Levamizol and prodigiozan exert the same effect on BALB/c mice and inhibit the RH suppression in CBA mice. In mature CBA mice these preparations potentiate HST. The splenocytes from young and aged BALB/c donors receiving the preparations oppositely induce the RH recipients.

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