The Effect of Radiation on Quality of Life throughout the Breast Reconstruction Process: A Prospective, Longitudinal Pilot Study of 200 Patients with Long-Term Follow-Up

Plastic and Reconstructive Surgery
Chris DevulapalliGedge D Rosson

Abstract

Despite well-established correlation of postmastectomy radiotherapy and surgical complications in breast reconstruction, its impact on patient reported outcomes is less clear. We sought to determine the effect of postmastectomy radiotherapy on patient reported outcomes throughout the breast reconstruction process. Patients undergoing prosthetic and autologous breast reconstruction from November 2010 to June 2013 were prospectively followed with BREAST-Q surveys (preoperatively, after expander placement, and 6 and 12 months after final reconstruction). Paired t test, Wilcoxon rank sum test, and multiple linear regression were used to determine the effect of radiation on patient reported outcomes. Two hundred patients were included in the study, of which 51 (25.5 percent) received postmastectomy radiotherapy. Prosthetic reconstruction was performed in 75 patients (37.5 percent), autologous reconstruction was performed in 118 (59 percent), and pure fat grafting was performed in seven (3.5 percent). At one-year follow-up, the nonirradiated group reported higher BREAST-Q scores when compared with the irradiated group, in Satisfaction with Breasts (p = 0.003), Psychosocial Well-being (p = 0.003), Sexual Well-being (p < 0.001), Physic...Continue Reading

References

Oct 1, 1995·Plastic and Reconstructive Surgery·G R EvansN Ainslie
Oct 2, 1997·The New England Journal of Medicine·J RagazI A Olivotto
Nov 5, 1997·Plastic and Reconstructive Surgery·J K WilliamsG Mackay
Jun 30, 2000·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C M ContantT Wiggers
Feb 15, 2001·International Journal of Radiation Oncology, Biology, Physics·E A KruegerL J Pierce
May 25, 2001·Plastic and Reconstructive Surgery· Edsander-Nord AM Wickman
May 8, 2002·Plastic and Reconstructive Surgery·Nicole E Rogers, Robert J Allen
Jun 5, 2003·Annals of Plastic Surgery·John A GirottoMaurice Y Nahabedian
Aug 12, 2003·International Journal of Radiation Oncology, Biology, Physics·Agnès V TalletGilles Houvenaeghel
Oct 7, 2004·Plastic and Reconstructive Surgery·Steven J Kronowitz, Geoffrey L Robb
Feb 8, 2006·Plastic and Reconstructive Surgery·Jeffrey A AschermanDuncan B Hughes
May 13, 2008·International Journal of Radiation Oncology, Biology, Physics·Jigna Desai JhaveriJay L Bosworth
Jun 2, 2009·Aesthetic Plastic Surgery·Pietro PanettiereDanilo Accorsi
Aug 1, 2009·Plastic and Reconstructive Surgery·Andrea L PusicStefan J Cano
Oct 7, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amy K AldermanSteven J Katz
Aug 3, 2010·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·E GrossD Cowen
Oct 23, 2010·Plastic and Reconstructive Surgery·Joshua FosnotJoseph M Serletti
Mar 3, 2011·Plastic and Reconstructive Surgery·Donald P BaumannGeoffrey L Robb
Jan 31, 2012·Plastic and Reconstructive Surgery·Stefan J CanoAndrea L Pusic
Mar 31, 2012·Expert Review of Pharmacoeconomics & Outcomes Research·Andrea L PusicPeter G Cordeiro
Jul 17, 2014·Plastic and Reconstructive Surgery·Stefan J CanoAndrea L Pusic
Oct 7, 2015·Annals of Surgical Oncology·Kyeong-Tae Lee, Goo-Hyun Mun

❮ Previous
Next ❯

Citations

Jan 17, 2020·Plastic and Reconstructive Surgery. Global Open·Kristina M CrawfordMatthew R Endara

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.