The effect of recombinant aminopeptidase A on hypertension in spontaneously hypertensive rats: its effect in comparison with candesartan

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
Masakazu IshiiShigehiko Mizutani

Abstract

An understanding of aminopeptidase A in hypertension is important, given its ability to cleave the N-terminal aspartic acid of potent vasoconstrictor angiotensin II. However, the role of aminopeptidase A in hypertension has received limited attention. Because we have succeeded in producing recombinant human aminopeptidase A, the effect of aminopeptidase A on systolic blood pressure in the spontaneously hypertensive rat was examined. Aminopeptidase A of 0.016 mg/kg was administrated intravenously to spontaneously hypertensive rats and blood pressure was monitored for 72 h. For repeated administration, aminopeptidase A doses of 0.016 mg/kg and 0.1-mg/kg doses of candesartan (an angiotensin II receptor 1 subtype blocker) were administrated daily in spontaneously hypertensive rats and blood pressure was monitored for 5 d. Bolus intravenous injection of aminopeptidase A at a dose of 0.016 mg/kg significantly decreased systolic blood pressure for 36 h in spontaneously hypertensive rats. A comparison of the antihypertensive effects of aminopeptidase A versus candesartan in spontaneously hypertensive rats showed that the effective dose of aminopeptidase A was about one-tenth that of candesartan. These results suggest the novel approach...Continue Reading

Citations

Jul 14, 2012·International Journal of Hypertension·John W WrightJoseph W Harding
Aug 13, 2013·Expert Opinion on Investigational Drugs·Shigehiko MizutaniHiroshi Kobayashi
Dec 30, 2014·Journal of the Science of Food and Agriculture·Jianbin LiuJian Xiong
Oct 16, 2010·Biochemical and Biophysical Research Communications·Ryuji KubotaToyoaki Murohara
Dec 13, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Rafael L MoraisJoão B Pesquero
Aug 9, 2020·International Journal of Molecular Sciences·Félix VargasJoaquín García-Estañ
Nov 26, 2019·Biochimica Et Biophysica Acta. Proteins and Proteomics·Shigehiko MizutaniKiyosumi Shibata

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